关于表达 6-硫酸神经氨酸的单核细胞（slanMo）的最新概念。

Current Concepts on 6-sulfo LacNAc Expressing Monocytes (slanMo).

机构信息

Department of Dermatology, Heidelberg University Hospital, Heidelberg, Germany.

Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, United States.

出版信息

Front Immunol. 2019 May 22;10:948. doi: 10.3389/fimmu.2019.00948. eCollection 2019.

DOI:10.3389/fimmu.2019.00948

PMID:31191513

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6540605/

Abstract

The human mononuclear phagocytes system consists of dendritic cells (DCs), monocytes, and macrophages having different functions in bridging innate and adaptive immunity. Among the heterogeneous population of monocytes the cell surface marker slan (6-sulfo LacNAc) identifies a specific subset of human CD14 CD16 non-classical monocytes, called slan monocytes (slanMo). In this review we discuss the identity and functions of slanMo, their contributions to immune surveillance by pro-inflammatory cytokine production, and cross talk with T cells and NK cells. We also consider the role of slanMo in the regulation of chronic inflammatory diseases and cancer. Finally, we highlight unresolved questions that should be the focus of future research.

摘要

人类单核吞噬细胞系统由树突状细胞（DCs）、单核细胞和巨噬细胞组成，它们在连接先天免疫和适应性免疫方面具有不同的功能。在单核细胞的异质性群体中，细胞表面标记物 slan（6-硫酸乳糖胺）鉴定出人类 CD14 CD16 非经典单核细胞的一个特定亚群，称为 slan 单核细胞（slanMo）。在这篇综述中，我们讨论了 slanMo 的特性和功能，它们通过产生促炎细胞因子在免疫监视中的贡献，以及与 T 细胞和 NK 细胞的相互作用。我们还考虑了 slanMo 在调节慢性炎症性疾病和癌症中的作用。最后，我们强调了应该成为未来研究重点的未解决问题。