Occupational Therapy, School of Allied Health, Human Sciences and Sport, College of Science, Health and Engineering, La Trobe University, Bundoora, VIC 3086, Australia.
Neurorehabilitation and Recovery, Stroke Division, Florey Institute of Neuroscience and Mental Health, Heidelberg VIC 3084, Australia.
Neural Plast. 2019 May 2;2019:5232374. doi: 10.1155/2019/5232374. eCollection 2019.
Neural plastic changes are experience and learning dependent, yet exploiting this knowledge to enhance clinical outcomes after stroke is in its infancy. Our aim was to search the available evidence for the core concepts of neuroplasticity, stroke recovery, and learning; identify links between these concepts; and identify and review the themes that best characterise the intersection of these three concepts.
We developed a novel approach to identify the common research topics among the three areas: neuroplasticity, stroke recovery, and learning. A concept map was created , and separate searches were conducted for each concept. The methodology involved three main phases: data collection and filtering, development of a clinical vocabulary, and the development of an automatic clinical text processing engine to aid the process and identify the unique and common topics. The common themes from the intersection of the three concepts were identified. These were then reviewed, with particular reference to the top 30 articles identified as intersecting these concepts.
The search of the three concepts separately yielded 405,636 publications. Publications were filtered to include only human studies, generating 263,751 publications related to the concepts of neuroplasticity ( = 6,498), stroke recovery ( = 79,060), and learning ( = 178,193). A cluster concept map (network graph) was generated from the results; indicating the concept nodes, strength of link between nodes, and the intersection between all three concepts. We identified 23 common themes (topics) and the top 30 articles that best represent the intersecting themes. A time-linked pattern emerged.
Our novel approach developed for this review allowed the identification of the common themes/topics that intersect the concepts of neuroplasticity, stroke recovery, and learning. These may be synthesised to advance a neuroscience-informed approach to stroke rehabilitation. We also identified gaps in available literature using this approach. These may help guide future targeted research.
神经可塑性是经验和学习依赖性的，但利用这一知识来提高中风后的临床疗效仍处于起步阶段。我们的目的是搜索神经可塑性、中风恢复和学习的核心概念的现有证据；确定这些概念之间的联系；并确定和审查最能描述这三个概念交叉点的主题。
我们开发了一种新的方法来识别这三个领域（神经可塑性、中风恢复和学习）中的共同研究主题。创建了一个概念图，并对每个概念分别进行了搜索。该方法涉及三个主要阶段：数据收集和过滤、临床词汇的开发以及开发自动临床文本处理引擎以辅助该过程并识别独特和共同的主题。从这三个概念的交叉点确定了共同主题。然后对这些主题进行了审查，特别参考了确定为交叉这些概念的前 30 篇文章。
分别搜索这三个概念产生了 405636 篇出版物。出版物被过滤以仅包括人类研究，生成了与神经可塑性（=6498）、中风恢复（=79060）和学习（=178193）概念相关的 263751 篇出版物。从结果中生成了一个聚类概念图（网络图）；表示概念节点、节点之间的链接强度以及所有三个概念之间的交叉。我们确定了 23 个共同主题（主题）和代表相交主题的前 30 篇文章。出现了一个时间相关的模式。
我们为本次综述开发的新方法允许识别神经可塑性、中风恢复和学习的概念交叉的共同主题/话题。这些可以综合起来，推进以神经科学为指导的中风康复方法。我们还通过这种方法确定了现有文献中的差距。这些可能有助于指导未来有针对性的研究。
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