氯胺酮、氯胺酮-曲马多和氯胺酮-酮咯酸对雏鸡的麻醉效果。

Anesthetic efficacy of ketamine, ketamine-tramadol and ketamine-ketorolac in chicks.

作者信息

Mousa Y J, Al-Zubaidy M H I

机构信息

Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq.

出版信息

Iran J Vet Res. 2019 Winter;20(1):33-38.

PMID:31191697

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6509909/

Abstract

BACKGROUND

Ketamine produces ordinary general anesthesia characterized by weak hypnosis and analgesia leading to complications during surgical operations.

AIMS

The aim of this study was to evaluate the combination of ketorolac or tramadol to enhance ketamine anesthesia in 7 to 20-day-old chicks and its feasibility and practical application for induction of general anesthesia in veterinary medicine.

METHODS

Hypnotic and analgesic Median Effective Doses (ED) of ketamine alone and combination with tramadol or ketorolac were determined by the up-and-down method, then the ED values of these combinations were used for measurement of hypnotic and analgesic criteria moreover, their effect on serum Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) was assayed.

RESULTS

Ketamine hypnosis and analgesia were increased when mixed with tramadol (26 and 39%) or ketorolac (27 and 40%), respectively. Ketamine-ketorolac mixture was better combination of inducing the faster onset of anesthesia and short recovery with the longest duration of action and enhancing analgesia when compared to ketamine alone or in combination with tramadol and is preferred for induction of anesthesia. The liver function enzymes, including AST and ALT, showed no significant difference among all above mentioned groups.

CONCLUSION

The data of this experimental study reveal the superiority of using ketorolac (instead of tramadol) in combination with ketamine for induction of general anesthesia in the chicks.

摘要

背景

氯胺酮产生的普通全身麻醉以弱催眠和镇痛为特征，会导致手术过程中出现并发症。

目的

本研究的目的是评估酮咯酸或曲马多与氯胺酮联合使用对7至20日龄雏鸡麻醉效果的增强作用，以及其在兽医学中诱导全身麻醉的可行性和实际应用。

方法

采用上下法测定氯胺酮单独使用以及与曲马多或酮咯酸联合使用时的催眠和镇痛半数有效剂量（ED），然后将这些联合用药的ED值用于测量催眠和镇痛标准，此外，还测定了它们对血清天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）的影响。

结果

氯胺酮与曲马多（分别提高26%和39%）或酮咯酸（分别提高27%和40%）混合使用时，催眠和镇痛效果增强。与氯胺酮单独使用或与曲马多联合使用相比，氯胺酮-酮咯酸混合物在诱导麻醉起效更快、恢复时间短、作用持续时间最长以及增强镇痛方面是更好的组合，是诱导麻醉的首选。包括AST和ALT在内的肝功能酶在上述所有组之间均无显著差异。