Pathi Jugajyoti, Vidya K C, Sangamesh N C
Department of Oral and Maxillofacial Surgery, Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, Odisha, India.
Department of Oral Medicine and Radiology, Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, Odisha, India.
Natl J Maxillofac Surg. 2020 Jul-Dec;11(2):236-240. doi: 10.4103/njms.NJMS_78_17. Epub 2020 Dec 16.
To compare the analgesic efficacy of preoperative intravenous (IV) ketorolac versus tramadol in preventing postoperative pain after mandibular third molar surgery.
Two hundred patients in the age group of 18-40 years with asymptomatic impacted mandibular molars were randomly allocated into one of the two groups (100 in each group) and underwent third molar surgery under local anesthesia. Group I received IV ketorolac 30 mg and Group II received IV tramadol 50 mg preoperatively. The difference in postoperative pain was assessed by five primary end points: pain intensity being measured hourly by Wong-Baker pain assessment scale for 6 h, onset of analgesia, duration of action, total number of analgesics consumed, and patient's global assessment.
Throughout the 6 h investigation period, patients reported significantly lower pain intensity scores, longer duration of action, lesser postoperative analgesic consumption, and better global assessment in ketorolac when compared to tramadol group. Patients in the ketorolac group significantly performed better than the tramadol group in terms of all parameters except onset of analgesia. All the drug-related complications were mild and did not require any investigation.
The result of the present study shows that preoperative IV ketorolac 30 mg is more effective than tramadol 50 mg for postoperative pain following third molar surgery.
比较术前静脉注射酮咯酸与曲马多预防下颌第三磨牙手术后疼痛的镇痛效果。
将200例年龄在18 - 40岁、无症状的下颌阻生磨牙患者随机分为两组(每组100例),在局部麻醉下接受第三磨牙手术。第一组术前静脉注射30毫克酮咯酸,第二组术前静脉注射50毫克曲马多。通过五个主要终点评估术后疼痛差异:采用面部表情疼痛评分量表每小时测量一次疼痛强度,持续6小时;镇痛起效时间;作用持续时间;消耗的镇痛药总数;以及患者整体评估。
在整个6小时的调查期内,与曲马多组相比,酮咯酸组患者报告的疼痛强度评分显著更低、作用持续时间更长、术后镇痛药消耗量更少且整体评估更好。除镇痛起效时间外,酮咯酸组患者在所有参数方面均显著优于曲马多组。所有与药物相关的并发症均较轻微,无需任何检查。
本研究结果表明,术前静脉注射30毫克酮咯酸在预防下颌第三磨牙手术后疼痛方面比50毫克曲马多更有效。