Stacy Mitchel R
Department of Surgery, The Ohio State University College of Medicine, Columbus, OH.
The Center for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, OH.
Curr Cardiovasc Imaging Rep. 2019 May;12(5). doi: 10.1007/s12410-019-9491-7. Epub 2019 Mar 27.
A variety of approaches and molecular targets have emerged in recent years for radionuclide-based imaging of atherosclerosis and vulnerable plaque using single photon emission computed tomography (SPECT) and positron emission tomography (PET), with numerous methods focused on characterizing the mechanisms underlying plaque progression and rupture. This review highlights the ongoing developments in both the preclinical and clinical environment for radionuclide imaging of atherosclerosis and atherothrombosis.
Numerous physiological processes responsible for the evolution of high-risk atherosclerotic plaque, such as inflammation, thrombosis, angiogenesis, and microcalcification, have been shown to be feasible targets for SPECT and PET imaging. For each physiological process, specific molecular markers have been identified that allow for sensitive non-invasive detection and characterization of atherosclerotic plaque.
The capabilities of SPECT and PET imaging continue to evolve for physiological evaluation of atherosclerosis. This review summarizes the latest developments related to radionuclide imaging of atherothrombotic diseases.
近年来,出现了多种方法和分子靶点,用于基于放射性核素的动脉粥样硬化和易损斑块成像,采用单光子发射计算机断层扫描(SPECT)和正电子发射断层扫描(PET)技术,众多方法聚焦于表征斑块进展和破裂的潜在机制。本综述重点介绍了动脉粥样硬化和动脉粥样硬化血栓形成放射性核素成像在临床前和临床环境中的持续进展。
已证明,导致高危动脉粥样硬化斑块演变的众多生理过程,如炎症、血栓形成、血管生成和微钙化,是SPECT和PET成像的可行靶点。对于每个生理过程,已鉴定出特定的分子标志物,可实现对动脉粥样硬化斑块的敏感无创检测和表征。
SPECT和PET成像在动脉粥样硬化生理评估方面的能力不断发展。本综述总结了与动脉粥样硬化血栓形成疾病放射性核素成像相关的最新进展。