为了治愈艾滋病毒，人们会冒怎样的死亡风险？原因又是什么？一项针对艾滋病毒感染者的调查。
What risk of death would people take to be cured of HIV and why? A survey of people living with HIV.
作者信息
Murray Benjamin R, Kratka Allison, Scherr Karen A, Eyal Nir, Blumenthal-Barby Jennifer, Freedberg Kenneth A, Kuritzkes Daniel R, Hammitt James K, Edifor Regina, Katz Madelaine N, Pollak Kathryn I, Zikmund-Fisher Brian J, Halpern Scott D, Barks Mary C, Ubel Peter A
机构信息
Duke University School of Medicine, Durham, NC, USA.
Duke University Fuqua School of Business, Durham, NC, USA.
出版信息
J Virus Erad. 2019 Apr 1;5(2):109-115. doi: 10.1016/S2055-6640(20)30052-2.
People living with HIV (PLWHIV) can reasonably expect near-normal longevity, yet many express a willingness to assume significant risks to be cured. We surveyed 200 PLWHIV who were stable on antiretroviral therapy (ART) to quantify associations between the benefits they anticipate from a cure and their risk tolerance for curative treatments. Sixty-five per cent expected their health to improve if cured of HIV, 41% predicted the virus would stop responding to medications over the next 20 years and 54% predicted experiencing serious medication side effects in the next 20 years. Respondents' willingness to risk death for a cure varied widely (median 10%, 75th percentile 50%). In multivariate analyses, willingness to risk death was associated with expected long-term side effects of ART, greater financial resources and being employed (all < 0.05) but was not associated with perceptions of how their health would improve if cured.
感染艾滋病毒的人（PLWHIV）可以合理预期接近正常的寿命，但许多人表示愿意承担巨大风险以实现治愈。我们对200名接受抗逆转录病毒疗法（ART）病情稳定的PLWHIV进行了调查，以量化他们预期从治愈中获得的益处与他们对治愈性治疗的风险承受能力之间的关联。65%的人预计如果治愈艾滋病毒，他们的健康状况会改善，41%的人预测在未来20年病毒将对药物产生耐药，54%的人预测在未来20年将出现严重的药物副作用。受访者为治愈而冒死亡风险的意愿差异很大（中位数为10%，第75百分位数为50%）。在多变量分析中，冒死亡风险的意愿与ART的预期长期副作用、更多的财务资源和就业情况相关（均P<0.05），但与如果治愈健康状况将如何改善的认知无关。
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