Lin Charles C, Lu Young, Patel Nilay A, Kiester P Douglas, Rosen Charles D, Bhatia Nitin N, Lee Yu-Po
University of California, Irvine, Orange, CA, USA.
Global Spine J. 2019 May;9(3):287-291. doi: 10.1177/2192568218793126. Epub 2018 Aug 13.
Retrospective database study.
To investigate the impact obstructive sleep apnea (OSA) has on perioperative complications, inpatient mortality, and costs in patients undergoing spinal fusions.
Hospitalizations for spinal fusion surgery between the years 2009 and 2011 were identified using the Nationwide Inpatient Sample and grouped into patients with and without OSA. Patient demographic data, comorbidities, hospital characteristics, hospitalization outcomes, and costs were extracted and compared. Multivariable logistic regressions were conducted to compare the in-hospital outcomes of patients undergoing spinal fusion with and without OSA.
A total of 107 451 (7.7%) OSA patients who underwent spinal fusions were identified from 2009 to 2011. Compared with patients without OSA, OSA patients were significantly older, more likely to be male, and have significantly greater comorbidity burden. Multivariable regression analysis demonstrated that OSA had a significant independent association with slightly increased respiratory (odds ratio [OR] = 1.13, confidence interval [CI] = 1.09-1.16; < .001), urinary and renal (OR = 1.11, CI = 1.07-1.16; < .001) or overall inpatient complications (OR = 1.05, CI = 1.02-1.05; < .001). OSA was also independently associated with significantly lower inpatient mortality (OR = 0.39, CI = 0.33-0.45; < .001).
While OSA confers greater comorbidity burden and is associated with slightly higher inpatient complication rates following spinal fusions, diagnosed OSA was not an independent predictor of inpatient mortality. A cautious interpretation of this finding is that on a national level, the current methods of preoperative medical optimization and inpatient management of OSA are satisfactory.
回顾性数据库研究。
探讨阻塞性睡眠呼吸暂停(OSA)对接受脊柱融合手术患者围手术期并发症、住院死亡率及费用的影响。
利用全国住院患者样本确定2009年至2011年间因脊柱融合手术住院的患者,并分为有OSA和无OSA两组。提取并比较患者的人口统计学数据、合并症、医院特征、住院结局及费用。进行多变量逻辑回归分析,比较有和无OSA的脊柱融合手术患者的院内结局。
2009年至2011年间共识别出107451例(7.7%)接受脊柱融合手术的OSA患者。与无OSA患者相比,OSA患者年龄显著更大,男性比例更高,合并症负担显著更重。多变量回归分析表明,OSA与呼吸(优势比[OR]=1.13,置信区间[CI]=1.09 - 1.16;P<0.001)、泌尿和肾脏(OR = 1.11,CI = 1.07 - 1.16;P<0.001)或总体住院并发症(OR = 1.05,CI = 1.02 - 1.05;P<0.001)略有增加显著独立相关。OSA还与显著更低的住院死亡率独立相关(OR = 0.39,CI = 0.33 - 0.45;P<0.001)。
虽然OSA带来更大的合并症负担,且与脊柱融合术后略高的住院并发症发生率相关,但确诊的OSA并非住院死亡率的独立预测因素。对此发现的谨慎解读是,在国家层面,目前OSA的术前医疗优化和住院管理方法是令人满意的。