明胶-胶原无纺支架为治疗皮肤浅层缺损提供了替代思泰福的选择。
Gelatin-Collagen Nonwoven Scaffold Provides an Alternative to Suprathel for Treatment of Superficial Skin Defects.
机构信息
At the time this article was written, at the Clinic of Plastic, Reconstructive, Hand and Burn Surgery, Eberhard Karls University, Tuebingen, Germany, Jennifer L. Schiefer, MD, was a resident; Rebekka Rath was a medical student; Manuel Held, MD, was a resident; Wiebke Petersen was a medical student; Jan-Ole Werner was a medical student; and Hans-Eberhard Schaller, MD, was Director. Afshin Rahmanian-Schwarz, MD, was Director, Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, Helios Clinic, University of Witten/Herdeke, Germany.
出版信息
Adv Skin Wound Care. 2019 Jul;32(7):329-332. doi: 10.1097/01.ASW.0000558047.07348.3b.
OBJECTIVE
To evaluate the effect of a new biologic gelatin-collagen nonwoven scaffold compared with a more common synthetic wound dressing on the healing of superficial wounds.
METHODS
Three superficial wounds with a depth of 0.5 mm and a length of 2.4 cm were created on the flanks of six minipigs using a skin dermatome. One wound on each pig was treated with the new nonwoven scaffold, one with the more common synthetic wound dressing, and one functioned as an untreated control wound. All three wounds were then covered with a semipermeable, sterile, transparent film.
RESULTS
After 7 days, complete wound closure of all wounds could be detected; epidermal thickness and the number of epidermal cells of all treated wounds were significantly increased compared with the control wounds. The nonwoven dressing showed slightly better results compared with the more common dressing.
CONCLUSIONS
The nonwoven scaffold is an interesting and competitive material for promoting epidermal wound healing. Because it is a biologic dressing, it degenerates completely and does not have to be removed from the wound. Further research should be conducted to compare this new dressing with other currently available wound treatments.
目的
评估新型生物明胶-胶原无纺支架与更常见的合成伤口敷料在促进浅层伤口愈合方面的效果。
方法
使用皮肤切片机在 6 头小型猪的侧腹上造成 3 个深度为 0.5 毫米、长度为 2.4 厘米的浅层伤口。每头猪的一个伤口用新型无纺支架处理，一个用更常见的合成伤口敷料处理，一个作为未处理的对照伤口。然后，所有三个伤口均用半透性、无菌、透明薄膜覆盖。
结果
7 天后，所有伤口均能检测到完全愈合；与对照伤口相比，所有治疗伤口的表皮厚度和表皮细胞数量均显著增加。无纺敷料的效果略优于更常见的敷料。
结论
无纺支架是一种促进表皮伤口愈合的有趣且有竞争力的材料。由于它是一种生物敷料，因此会完全降解，无需从伤口中去除。应进一步研究该新型敷料与其他目前可用的伤口处理方法的比较。
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