维持性电抽搐治疗对精神分裂症患者的临床疗效：一项回顾性队列研究。
Clinical Effectiveness of Maintenance Electroconvulsive Therapy in Patients with Schizophrenia: A Retrospective Cohort Study.
机构信息
From the Temerty Centre for Therapeutic Brain Intervention, Campbell Family Research Institute, Centre for Addiction and Mental Health.
出版信息
J ECT. 2020 Mar;36(1):42-46. doi: 10.1097/YCT.0000000000000613.
OBJECTIVE
This study aimed to assess the clinical effectiveness and cognitive effects of maintenance electroconvulsive therapy (mECT) in patients with schizophrenia or schizoaffective disorder and explore factors associated with both outcomes.
METHODS
In this retrospective cohort study, we examined clinical records of 47 patients with a Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) diagnosis of schizophrenia or schizoaffective disorder treated with mECT at an academic mental health hospital between April 2010 and July 2016. Sixty-two mECT courses were reviewed. We assessed clinical effectiveness and cognitive effects as well as factors associated with response to treatment, including psychiatric diagnosis, concomitant pharmacological treatment, and previous treatment response.
RESULTS
Maintenance electroconvulsive therapy was able to maintain clinical response in 48 (77%) treatment courses. Significant cognitive adverse effects were reported in 7 (11%) of the courses. Use of antipsychotic, antidepressant or benzodiazepine medications, psychiatric disorder, and sex were not associated with response.
CONCLUSION
This study shows meaningful clinical effectiveness and good tolerability of mECT in patients with resistant schizophrenia over extended periods.
目的
本研究旨在评估维持性电抽搐治疗（mECT）在精神分裂症或分裂情感障碍患者中的临床疗效和认知影响，并探讨与这两个结果相关的因素。
方法
在这项回顾性队列研究中，我们检查了 2010 年 4 月至 2016 年 7 月在一家学术精神卫生医院接受 mECT 治疗的 47 名符合《精神障碍诊断与统计手册》（第四版）精神分裂症或分裂情感障碍诊断标准的患者的临床记录。共回顾了 62 次 mECT 疗程。我们评估了临床疗效和认知影响，以及与治疗反应相关的因素，包括精神科诊断、同时进行的药物治疗和以前的治疗反应。
结果
维持性电抽搐治疗能够在 48（77%）次治疗中维持临床反应。7（11%）次疗程报告有显著的认知不良影响。抗精神病药物、抗抑郁药物或苯二氮䓬类药物的使用、精神疾病和性别与反应无关。
结论
这项研究表明，mECT 在延长时间内对耐药性精神分裂症患者具有显著的临床疗效和良好的耐受性。
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