氟西汀对胆管癌患者化疗所致神经性厌食症的疗效。
Efficacy of fluoxetine for anorexia nervosa caused by chemotherapy in patients with cholangiocarcinoma.
作者信息
Guo Lin-Qi, Sun Hua-Wei, Zhang Chun-Ye, Feng Yao, Teng Xin-Li, Qu Yi-Kun
机构信息
Second Ward of Surgery Department.
Department of Chemotherapy and Radiotherapy.
出版信息
Medicine (Baltimore). 2019 Jun;98(24):e15945. doi: 10.1097/MD.0000000000015945.
BACKGROUND
Fluoxetine has been reported to treat anorexia nervosa (AN) caused by chemotherapy in patients with cholangiocarcinoma effectively. However, no study systematically investigated its efficacy and safety. Thus, this study will systematically assess its efficacy and safety for AN caused by chemotherapy in patients with cholangiocarcinoma.
METHODS
A comprehensive literature search for relevant studies will be conducted from the following databases from inception to the present: MEDILINE, EMBASE, Cochrane Library, Web of Science, PSYCINFO, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. All randomized controlled trials on assessing the efficacy and safety of fluoxetine for AN caused by chemotherapy in patients with cholangiocarcinoma will be considered for inclusion in this study. RevMan V.5.3 software will be used for risk of bias assessment and statistical analysis.
RESULTS
This study will summarize the latest evidence of fluoxetine for AN caused by chemotherapy in patients with cholangiocarcinoma through assessing outcomes of weight, depression, anxiety, and quality of life. Additionally, any adverse events will also be analyzed.
CONCLUSION
The findings of this study will provide most recent evidence of fluoxetine for AN caused by chemotherapy in patients with cholangiocarcinoma.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42019131583.
背景
据报道，氟西汀可有效治疗胆管癌患者化疗所致的神经性厌食症（AN）。然而，尚无研究对其疗效和安全性进行系统调查。因此，本研究将系统评估其对胆管癌患者化疗所致AN的疗效和安全性。
方法
将从以下数据库开展全面的文献检索，检索时间从建库至当前：医学索引数据库（MEDILINE）、荷兰医学文摘数据库（EMBASE）、考克兰图书馆、科学引文索引数据库（Web of Science）、心理学文摘数据库（PSYCINFO）、补充与替代医学数据库、中国生物医学文献数据库以及中国知网。所有评估氟西汀对胆管癌患者化疗所致AN疗效和安全性的随机对照试验都将纳入本研究。将使用RevMan V.5.3软件进行偏倚风险评估和统计分析。
结果
本研究将通过评估体重、抑郁、焦虑和生活质量等结局，总结氟西汀治疗胆管癌患者化疗所致AN的最新证据。此外，还将分析任何不良事件。
结论
本研究结果将提供氟西汀治疗胆管癌患者化疗所致AN的最新证据。
系统评价注册
国际前瞻性系统评价注册库（PROSPERO）CRD42019131583。
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