Xu Yuhao, Xu Jianhui, Zhang Jian, Cai Zhirong, Wei Hong, Yu Ming, Li Yuefeng
Department of Neurology.
Department of Radiology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Medicine (Baltimore). 2019 Jun;98(24):e16002. doi: 10.1097/MD.0000000000016002.
Creutzfeldt-Jakob disease (CJD) is an infrequent and rapidly fatal neurodegenerative disease without effective cure. Common presentations of CJD include rapidly progressive cognitive decline, behavioral changes, cerebellar dysfunction, and visual disturbances. Since clinicians may see only very few cases during their professional career, it is important to be familiar with the clinical presentation and progression, and allow for quick diagnosis.
We reported an elderly woman had recurrent attacks of dizziness in the preceding month. She began to suffer progression of memory disturbance half a month before admission and was admitted to our department in a coma.
The accessory examinations of magnetic resonance imaging (MRI), electroencephalography (EEG), 14-3-3 protein in cerebrospinal fluid and S100 protein in serum support the diagnosis of sporadic CJD (sCJD). Combined with this evidence and clinical symptom, we made a clinical diagnosis of sCJD.
Supportive treatment.
After 2 months of active treatment, the patient's condition had not improved, and the patient died 82 days after admission.
Clinicians should attach importance to sCJD, which is significant for the prevention of transmission and treatment.
克雅氏病（CJD）是一种罕见且迅速致命的神经退行性疾病，目前尚无有效治愈方法。CJD的常见症状包括快速进展的认知衰退、行为改变、小脑功能障碍和视觉障碍。由于临床医生在其职业生涯中可能仅见过极少数病例，因此熟悉其临床表现和病程并实现快速诊断非常重要。
我们报告了一名老年女性，在前一个月反复出现头晕发作。入院前半个月开始出现记忆障碍进展，入院时昏迷，被收入我科。
磁共振成像（MRI）、脑电图（EEG）、脑脊液14-3-3蛋白和血清S100蛋白等辅助检查支持散发性克雅氏病（sCJD）的诊断。结合这些证据和临床症状，我们做出了sCJD的临床诊断。
支持性治疗。
经过2个月的积极治疗，患者病情未改善，入院82天后死亡。
临床医生应重视sCJD，这对预防传播和治疗具有重要意义。
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