Deumer J, Frentzen M, Meinke M C
MVZ Erstes Zahnärztliches Lasercentrum Berlin, Gatower Straße 296, 14089 Berlin, Germany.
Department of Operative and Preventive Dentistry, Bonn University, Dental Faculty, Germany.
Heliyon. 2019 May 17;5(5):e01661. doi: 10.1016/j.heliyon.2019.e01661. eCollection 2019 May.
This retrospective data-collection study aims to explain how the active matrix-metalloproteinase-8-titer (aMMP-titer) influences the immune response of the subject. This is done through monotherapy scaling and root planing (SRP) which is then compared to SRP combined with antimicrobial photothermal therapy (aPTT, Emundo®).
Data collection was monocentric, randomized and split-mouth based. A study group of twenty patients with chronic periodontal disease with a periodontal pocket depth (PPD) 4 mm ≤ PPD ≤8 mm, a periodontal screening index (PSI: > 3), and a gingival recession ≤2 mm were selected.A diode laser, manufactured by A.R.C. Laser GmbH, with 810 nm wavelength was used. This device implemented three different light transmission systems for transgingival and intra-gingival irradiation. Power settings between 200 and 300 mW were deployed for 10 s during all treatment steps. The photothermic dye of EmunDo® system (A.R.C. Laser GmbH) was infracyaningreen.The adjuvant effect of the antimicrobial photothermal therapy (aPTT) with EmunDo® in combination with conventional SRP on the teeth 15 and 35 was compared with the results of monotherapy SRP on teeth 25 and 45.
A reduction of the aMMP-8-titer in gingival crevicular fluid (GCF) was observed in both groups (follow up group and control group) after one month. However; the decrease in the follow up group under SRP in combination with aPTT was significantly more pronounced. The periodontal pocket depths was reduced in both treatment groups. The periodontal probing depth (in mm) shows a larger decrease of the periodontal pocket depth within the follow up group (SPR with aPTT) compared with the control group (SRP).
The aMMP-8-titer showed differences in both groups prior to and after treatment. Active matrix-metalloproteinase-8 (aMMP-8) as a reference parameter for path control in antimicrobial photothermal therapy (aPTT) seems acceptable.
这项回顾性数据收集研究旨在解释活性基质金属蛋白酶-8滴度（aMMP-titer）如何影响受试者的免疫反应。这是通过单一疗法龈下刮治术和根面平整术（SRP）来完成的，然后将其与SRP联合抗菌光热疗法（aPTT，Emundo®）进行比较。
数据收集是以单中心、随机和分口为基础的。选取了20名患有慢性牙周病的研究组患者，其牙周袋深度（PPD）为4毫米≤PPD≤8毫米，牙周筛查指数（PSI：>3），且牙龈退缩≤2毫米。使用了由A.R.C. Laser GmbH制造的波长为810纳米的二极管激光。该设备实施了三种不同的光传输系统用于经龈和龈内照射。在所有治疗步骤中，功率设置为200至300毫瓦，持续10秒。EmunDo®系统（A.R.C. Laser GmbH）的光热染料为近红外菁绿。将EmunDo®抗菌光热疗法（aPTT）联合传统SRP对15号和35号牙的辅助效果与25号和45号牙的单一疗法SRP结果进行比较。
两组（随访组和对照组）在一个月后牙龈沟液（GCF）中的aMMP-8滴度均有所降低。然而，随访组中SRP联合aPTT后的下降更为显著。两个治疗组的牙周袋深度均有所降低。与对照组（SRP）相比，随访组（SRP联合aPTT）的牙周探诊深度（以毫米为单位）显示牙周袋深度下降幅度更大。
两组治疗前后的aMMP-8滴度均有差异。活性基质金属蛋白酶-8（aMMP-8）作为抗菌光热疗法（aPTT）中病情控制的参考参数似乎是可以接受的。
