Keller R, Keist R
Institute for Immunology and Virology, University of Zurich, Switzerland.
Eur J Immunol. 1987 Nov;17(11):1665-8. doi: 10.1002/eji.1830171124.
Rat bone marrow-derived mononuclear phagocytes (BMM phi), induced to differentiate in vitro and homogeneous with respect to the cell lineage, were interacted with various macrophage-activating agents. The effect of these agents on the secretion of interleukin 1 (IL 1) activity and on the development of tumoricidal capacity was comparatively assessed. The findings show that IL 1 secretion is considerably enhanced by macrophage-activating factor and by recombinant interferon-gamma but remained unaffected or was even suppressed by heat-killed C. parvum or Listeria monocytogenes. In contrast, lymphokines as well as C. parvum and Listeria were similarly potent in inducing in BMM phi a tumoricidal state. The findings indicate that induction of IL 1 secretion and of tumoricidal activity are not necessarily closely linked phenomena.
大鼠骨髓来源的单核吞噬细胞（BMM phi），经体外诱导分化且细胞谱系均一，与多种巨噬细胞激活剂相互作用。比较评估了这些试剂对白介素1（IL 1）活性分泌以及杀肿瘤能力发展的影响。研究结果表明，巨噬细胞激活因子和重组干扰素-γ可显著增强IL 1的分泌，但热灭活的微小隐孢子虫或单核细胞增生李斯特菌对其无影响甚至有抑制作用。相比之下，淋巴因子以及微小隐孢子虫和李斯特菌在诱导BMM phi产生杀肿瘤状态方面同样有效。研究结果表明，IL 1分泌的诱导和杀肿瘤活性不一定是紧密相关的现象。
