Torda T, Culman J, Petriková M
Institute of Experimental Endocrinology, Slovak Acad. Sci., Bratislava, Czechoslovakia.
Eur J Pharmacol. 1987 Sep 11;141(2):305-8. doi: 10.1016/0014-2999(87)90276-7.
The distribution of phenylethanolamine-N-methyltransferase (PNMT), the epinephrine-forming enzyme in the adult rat heart atria and ventricles was studied. The activity of the enzyme in the hearts of adult rats is very low; a significantly higher activity was found in the atria than in the ventricles. A significant increase in PNMT activity was found in all heart areas examined in 6-hydroxydopamine-treated rats compared to vehicle-treated rats. The increased PNMT activity might reflect compensatory or adaptation processes secondary to the destruction of the peripheral sympathetic nerve terminals.
研究了苯乙醇胺 - N - 甲基转移酶（PNMT）在成年大鼠心脏心房和心室中的分布，该酶是生成肾上腺素的酶。成年大鼠心脏中该酶的活性非常低；在心房中发现的活性明显高于心室。与用载体处理的大鼠相比，在6 - 羟基多巴胺处理的大鼠的所有检查心脏区域中均发现PNMT活性显著增加。PNMT活性的增加可能反映了外周交感神经末梢破坏后的代偿或适应过程。
