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基于网络的自助干预(有无聊天咨询)对减少可卡因滥用者的可卡因使用情况:一项三臂随机对照试验的结果

Web-based self-help with and without chat counseling to reduce cocaine use in cocaine misusers: Results of a three-arm randomized controlled trial.

作者信息

Schaub Michael P, Castro Raquel Paz, Wenger Andreas, Baumgartner Christian, Stark Lars, Ebert David D, Quednow Boris B, Haug Severin

机构信息

Swiss Research Institute for Public Health and Addiction at the University of Zurich, Konradstrasse 32, P. O. Box, 8005 Zurich, Switzerland.

Arud, Centres for Addiction Medicine, Konradstrasse 32, 8005 Zurich, Switzerland.

出版信息

Internet Interv. 2019 May 22;17:100251. doi: 10.1016/j.invent.2019.100251. eCollection 2019 Sep.

Abstract

BACKGROUND

In recent years, cocaine use has increased in many countries, but only a minority of users seek treatment. Cognitive behavioral therapy (CBT) is seen as first-choice face-to-face treatment. However, a web-based intervention might serve as an alternative.

AIMS

To test the efficacy of a web-based self-help intervention, with and without chat counseling, grounded in CBT, at reducing cocaine use in cocaine misusers not in treatment for a substance use disorder.

METHODS

Subjects were randomly assigned to (1) a self-help intervention with chat support, (2) a self-help intervention without chat support, or (3) a waiting list control group. The fully-automated self-help program consisted of eight modules based on motivational interviewing, self-control practices and CBT. The primary outcome was the quantity of cocaine use per week. Secondary outcomes included frequency of cocaine and other substance use and mental health symptoms. Linear regression analysis was performed to investigate changes in primary and secondary outcomes.

RESULTS

In total, 416 users registered online for the trial, of whom 311 completed the baseline assessment. Participants were predominantly male (73%) and averaged 33 years old (SD = 7.6). Despite considerable efforts on our part, only 47 of 311 (15.1%) subjects completed the 6-month follow-up assessment. Frequency of cocaine use and severity of cocaine dependence decreased only in the intervention groups. No significant difference in the primary outcome was observed between the study arms, but several differences in secondary outcomes were observed by complete case analyses.

CONCLUSIONS

Many cocaine misusers from the general population and not otherwise in treatment could be reached and decreased their cocaine use utilizing a CBT-based online intervention. However, due to the high percentage of dropouts and serious difficulties reaching subjects for follow-up assessments, no conclusions can be drawn regarding study arm differences. Implications for future studies are discussed.

摘要

背景

近年来,许多国家可卡因的使用呈上升趋势,但只有少数使用者寻求治疗。认知行为疗法(CBT)被视为首选的面对面治疗方法。然而,基于网络的干预措施可能是一种替代方案。

目的

测试一种基于网络的自助干预措施(有或没有聊天咨询)在减少未接受物质使用障碍治疗的可卡因滥用者的可卡因使用方面的疗效,该干预措施以认知行为疗法为基础。

方法

将受试者随机分为三组:(1)有聊天支持的自助干预组;(2)无聊天支持的自助干预组;(3)等待名单对照组。全自动自助计划由八个基于动机访谈、自我控制实践和认知行为疗法的模块组成。主要结局是每周可卡因的使用量。次要结局包括可卡因和其他物质使用的频率以及心理健康症状。进行线性回归分析以研究主要和次要结局的变化。

结果

共有416名使用者在线注册参加试验,其中311人完成了基线评估。参与者主要为男性(73%),平均年龄33岁(标准差=7.6)。尽管我们付出了巨大努力,但311名受试者中只有47人(15.1%)完成了6个月的随访评估。仅干预组的可卡因使用频率和可卡因依赖严重程度有所下降。各研究组之间在主要结局上未观察到显著差异,但通过完全病例分析在次要结局上观察到了一些差异。

结论

可以接触到许多来自普通人群且未接受其他治疗的可卡因滥用者,并通过基于认知行为疗法的在线干预减少他们的可卡因使用。然而,由于辍学率高以及在联系受试者进行随访评估时遇到严重困难,无法就各研究组之间的差异得出结论。讨论了对未来研究的启示。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7472/6536739/afdbfd0ddc37/gr1.jpg

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