成年纹状体和前额叶皮质的LINE1与甲基化，其暴露于产前免疫激活。
LINE1 and methylation of the adult striatum and prefrontal cortex exposed to prenatal immune activation.
作者信息
Basil Paul, Li Qi, Sham Pak-Chung, McAlonan Grainne M
机构信息
Department of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong S.A.R., China.
Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Data Brief. 2019 May 23;25:104003. doi: 10.1016/j.dib.2019.104003. eCollection 2019 Aug.
Prenatal exposure to infection and inflammation increases the risk of neurodevelopmental disorders such as schizophrenia and autism. The etiology could be partly through transgenerational and modifiable DNA methylation changes in the adult offspring's brain. This data descriptor presents a dataset of global DNA methylation (using LINE1 assay) and promoter methylation in adolescent and adult brain tissue of offspring exposed to prenatal immune activation on gestation day 9 and offspring of saline exposed mice. PCR based methylation assays using Sequenom EpiTYPER was used to quantify DNA methylation at promoter CpG methylation of Long Interspersed Elements-1 (LINE1 or L1) and . The dataset also includes global DNA methylation and promoter methylation profile at 6 and 12 weeks following early dietary intervention with omega-3 (n-3) PUFA.
产前暴露于感染和炎症会增加患精神分裂症和自闭症等神经发育障碍的风险。其病因可能部分是通过成年后代大脑中可遗传且可改变的DNA甲基化变化。本数据描述提供了一个数据集，该数据集包含在妊娠第9天暴露于产前免疫激活的后代以及盐水暴露小鼠后代的青少年和成年脑组织中的全基因组DNA甲基化（使用LINE1检测法）和启动子甲基化情况。使用Sequenom EpiTYPER基于PCR的甲基化检测法来定量长散在元件-1（LINE1或L1）启动子CpG甲基化处的DNA甲基化。该数据集还包括在早期用ω-3（n-3）多不饱和脂肪酸进行饮食干预6周和12周后的全基因组DNA甲基化和启动子甲基化图谱。
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