中性粒细胞与淋巴细胞比值（NLR）无法预测弥漫性大B细胞淋巴瘤的预后。
Neutrophil-to-lymphocyte ratio (NLR) fails to predict outcome of diffuse large B cell lymphoma.
作者信息
Azuma Yoshiko, Nakaya Aya, Fujita Shinya, Satake Atsushi, Nakanishi Takahisa, Tsubokura Yukie, Saito Ryo, Konishi Akiko, Hotta Masaaki, Yoshimura Hideaki, Ishii Kazuyoshi, Ito Tomoki, Nomura Shosaku
机构信息
First Department of Internal Medicine, Kansai Medical University, 2-5-1, Shin-machi, Hirakata, Osaka 573-1010, Japan.
出版信息
Leuk Res Rep. 2019 May 25;12:100173. doi: 10.1016/j.lrr.2019.100173. eCollection 2019.
BACKGROUND
Neutrophil-to-lymphocyte ratio (NLR) has been recognized as a poor prognostic indicator in various solid tumors.
METHODS
We retrospectively analyzed 530 patients with de novo DLBCL who were diagnosed from April 2002 to November 2017.
RESULTS
The median age of patients was 69 (range, 20-95) years, and 59% were male. The optimal cutoff for NLR was 5.2. NLR (5.2) was not associated with overall and progression free survival.
CONCLUSION
Our study failed to reveal the predictive value of NLR and demonstrated that the NCCN-IPI might be the most powerful predictor in DLBCL.
背景
中性粒细胞与淋巴细胞比值（NLR）已被认为是多种实体瘤预后不良的指标。
方法
我们回顾性分析了2002年4月至2017年11月期间确诊的530例初发性弥漫性大B细胞淋巴瘤（DLBCL）患者。
结果
患者的中位年龄为69岁（范围20 - 95岁），59%为男性。NLR的最佳临界值为5.2。NLR（5.2）与总生存期和无进展生存期无关。
结论
我们的研究未能揭示NLR的预测价值，并表明NCCN国际预后指数（NCCN-IPI）可能是DLBCL中最有力的预测指标。
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