Assistant Professor of Medicine and Clinical Hematology, Consultant Physician and Clinical Hematologist, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region- Iraq.
Assistant Professor of Clinical Hematology, Consultant Clinical Hematologist, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region- Iraq.
Cell Mol Biol (Noisy-le-grand). 2021 Nov 25;67(3):61-68. doi: 10.14715/cmb/2021.67.3.8.
Diffuse large B-cell lymphoma (DLBCL) is an aggressive and rapid-growing form of non-Hodgkin lymphoma (NHL). The objective of this research was to assess the predictive role of lymphocyte to monocyte ratio (LMR), red cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) values in the survival of DLBCL patients. A retrospective analysis of 136 DLBCL patients admitted to Nanakali Hospital for blood diseases and oncology from 2010-2020 was done. We assessed the correlation of LMR, RDW and NLR with patients' characteristics and the impact on survival by the Kaplan-Meier method, the log-rank test, and Cox regression models for multivariate analysis. The complete remission rate was 61.7%, with a 5- year overall survival (OS) and progression-free survival (PFS) of 59.5% and 60%, respectively. The Log-rank test showed that LMR was significantly correlated with Ann Arbor staging (p= 0.040). There is a significant association between RDW and Eastern Cooperative Oncology Group performance status (ECOG-performance status) (p= 0.022), B symptoms (p= 0.026), Revised International prognostic index (R-IPI) (p= 0.004), lactate dehydrogenase (LDH) (p= 0.021), and beta 2 microglobulin (B2MG) (p= 0.007), whereas NLR had a significant correlation with LDH only (p=0.016). There were no significant differences in the 5-year OS or PFS in patients with different levels of RDW, LMR, and NLR. LMR, RDW and NLR were correlated with many of patients' characteristics. However, none of the LMR, RDW and NLR did possess value to predict OS and PFS, and they cannot be used as biomarkers for survival evaluation of DLBCL.
弥漫性大 B 细胞淋巴瘤（DLBCL）是一种侵袭性和快速生长的非霍奇金淋巴瘤（NHL）。本研究旨在评估淋巴细胞与单核细胞比值（LMR）、红细胞分布宽度（RDW）和中性粒细胞与淋巴细胞比值（NLR）值对 DLBCL 患者生存的预测作用。对 2010 年至 2020 年期间在纳纳卡利医院血液疾病和肿瘤科就诊的 136 例 DLBCL 患者进行回顾性分析。我们通过 Kaplan-Meier 法、对数秩检验和 Cox 回归模型进行多变量分析，评估了 LMR、RDW 和 NLR 与患者特征的相关性及其对生存的影响。完全缓解率为 61.7%，5 年总生存率（OS）和无进展生存率（PFS）分别为 59.5%和 60%。Log-rank 检验显示，LMR 与 Ann Arbor 分期显著相关（p=0.040）。RDW 与东部肿瘤协作组体能状态（ECOG-performance status）（p=0.022）、B 症状（p=0.026）、修订后的国际预后指数（R-IPI）（p=0.004）、乳酸脱氢酶（LDH）（p=0.021）和β2 微球蛋白（B2MG）（p=0.007）显著相关，而 NLR 仅与 LDH 显著相关（p=0.016）。不同 RDW、LMR 和 NLR 水平的患者 5 年 OS 或 PFS 无显著差异。LMR、RDW 和 NLR 与患者的许多特征相关。然而，LMR、RDW 和 NLR 均不能预测 OS 和 PFS，不能作为 DLBCL 生存评估的生物标志物。
