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周期性变形对异种心脏瓣膜生物材料的影响。

Effect of cyclic deformation on xenogeneic heart valve biomaterials.

机构信息

Department of Veterinary Medicine: Medicine and Epidemiology, University of California, Davis, Davis, CA, United States of America.

Department of Cardiovascular Diseases, Mayo Clinic, SW, Rochester, MN, United States of America.

出版信息

PLoS One. 2019 Jun 13;14(6):e0214656. doi: 10.1371/journal.pone.0214656. eCollection 2019.

Abstract

Glutaraldehyde-fixed bovine pericardium is currently the most popular biomaterial utilized in the creation of bioprosthetic heart valves. However, recent studies indicate that glutaraldehyde fixation results in calcification and structural valve deterioration, limiting the longevity of bioprosthetic heart valves. Additionally, glutaraldehyde fixation renders the tissue incompatible with constructive recipient cellular repopulation, remodeling and growth. Use of unfixed xenogeneic biomaterials devoid of antigenic burden has potential to overcome the limitations of current glutaraldehyde-fixed biomaterials. Heart valves undergo billion cycles of opening and closing throughout the patient's lifetime. Therefore, understanding the response of unfixed tissues to cyclic loading is crucial to these in a heart valve leaflet configuration. In this manuscript we quantify the effect of cyclic deformation on cycle dependent strain, structural, compositional and mechanical properties of fixed and unfixed tissues. Glutaraldehyde-fixed bovine pericardium underwent marked cyclic dependent strain, resulting from significant changes in structure, composition and mechanical function of the material. Conversely, unfixed bovine pericardium underwent minimal strain and maintained its structure, composition and mechanical integrity. This manuscript demonstrates that unfixed bovine pericardium can withstand cyclic deformations equivalent to 6 months of in vivo heart valve leaflet performance.

摘要

戊二醛固定牛心包目前是生物瓣最常用的生物材料。然而,最近的研究表明,戊二醛固定会导致钙化和结构瓣膜退化,限制生物瓣的使用寿命。此外,戊二醛固定使组织与构建受体细胞再增殖、重塑和生长不兼容。使用无抗原负担的未固定异种生物材料有可能克服目前戊二醛固定生物材料的局限性。心脏瓣膜在患者的一生中经历数十亿次的开合循环。因此,了解未固定组织对循环加载的反应对于心脏瓣膜叶瓣结构至关重要。在本文中,我们定量分析了循环变形对固定和未固定组织的循环依赖性应变、结构、组成和机械性能的影响。戊二醛固定牛心包经历了明显的循环依赖性应变,这是由于材料的结构、组成和机械功能发生了显著变化。相反,未固定的牛心包经历了最小的应变,并保持了其结构、组成和机械完整性。本文证明,未固定的牛心包可以承受相当于 6 个月体内心脏瓣膜叶瓣性能的循环变形。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d738/6563958/cb1744c0317c/pone.0214656.g001.jpg

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