从小脑改变到情绪障碍：系统综述。
From cerebellar alterations to mood disorders: A systematic review.
机构信息
Ataxia Laboratory, IRCCS Fondazione Santa Lucia, Via Ardeatina 306-354, 00179, Rome, Italy.
Sapienza University of Rome, Via dei Marsi 78, 00185, Rome, Italy.
出版信息
Neurosci Biobehav Rev. 2019 Aug;103:21-28. doi: 10.1016/j.neubiorev.2019.06.008. Epub 2019 Jun 10.
BACKGROUND
Several studies have shown cerebellar abnormalities during depressive and manic states, although the specific cerebellar role in mood fluctuations remains poorly defined. Therefore, the study of pathologies characterized by frequent mood swings, such as bipolar disorder, is of great interest to investigate the relationship between the cerebellum and mood alterations.
METHODS
A systematic literature search on the occurrence of mood disorders in patients with cerebellar pathologies (1 research strategy) and on the presence of cerebellar alterations in mood disorders (2 research strategy) was conducted using the PubMed electronic Internet database. For this systematic review all information was written based on the PRISMA-P statement.
RESULTS
The results of the 1 research strategy generated 9 articles, and in one of these, a direct correlation between cerebellar damage and the onset of mood disorder was reported. The 2 research strategy generated 14 articles that were grouped according to the patient's mood phase (manic or depressive) or diagnosis (bipolar I or bipolar II).
CONCLUSIONS
The present review suggests that the cerebellum should be considered a key structure involved in the regulation of mood.
背景
几项研究表明，在抑郁和躁狂状态下小脑存在异常，尽管小脑在情绪波动中的特定作用仍未得到明确界定。因此，研究以情绪波动频繁为特征的病理学，如双相情感障碍，对于研究小脑与情绪改变之间的关系非常有意义。
方法
使用 PubMed 电子互联网数据库对小脑病变患者出现情绪障碍（1 项研究策略）和情绪障碍患者存在小脑改变（2 项研究策略）进行了系统的文献检索。本系统评价的所有信息均基于 PRISMA-P 声明书写。
结果
第 1 项研究策略的结果产生了 9 篇文章，其中一篇报道了小脑损伤与情绪障碍发作之间的直接相关性。第 2 项研究策略产生了 14 篇文章，这些文章根据患者的情绪阶段（躁狂或抑郁）或诊断（双相 I 型或双相 II 型）进行了分组。
结论
本综述表明，小脑应被视为参与调节情绪的关键结构。
Zotero 插件