MBT-2肿瘤诱导的小鼠局部骨溶解模型及其对依替膦酸二钠的反应性
A model of localized osteolysis induced by the MBT-2 tumor in mice and its responsiveness to etidronate disodium.
作者信息
Nemoto R, Uchida K, Tsutsumi M, Koiso K, Satou S, Satou T
机构信息
Department of Urology, University of Tsukuba, Ibaraki, Japan.
出版信息
J Cancer Res Clin Oncol. 1987;113(6):539-43. doi: 10.1007/BF00390862.
Abstract
A new experimental method to test the effect of drugs on tumor-induced osteolysis using a bladder tumor in mice has been designed. The method consisted of inoculating MBT-2 tumor cells s.c. over the calvaria in mice, resulting in a local tumor causing fragmentation of the bone. This was accompanied by adjacent osteoplastic changes, which were evaluated by X-ray and histological examination. Etidronate disodium (EHDP), a diphosphonate derivative, at a dose of 3 mg/kg to 30 mg/kg s.c. protected the bone by decreasing the extent of osteolysis as judged by the same criteria. Therapy with EHDP prolonged the survival period. This inhibition was obtained with no apparent effect on the growth of the MBT-2 tumor.
摘要
一种利用小鼠膀胱肿瘤来测试药物对肿瘤诱导的骨溶解作用的新实验方法已经设计出来。该方法包括在小鼠颅骨皮下接种MBT-2肿瘤细胞，导致局部肿瘤引起骨碎裂。这伴随着相邻的骨形成变化，通过X射线和组织学检查进行评估。依替膦酸二钠（EHDP），一种双膦酸盐衍生物，皮下注射剂量为3mg/kg至30mg/kg，根据相同标准判断，通过减少骨溶解程度来保护骨骼。用EHDP治疗可延长生存期。这种抑制作用在对MBT-2肿瘤生长没有明显影响的情况下获得。
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