Qu Guidong, Shi Yunfei
Elderly Thoracic Surgery, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
Zhongguo Fei Ai Za Zhi. 2019 Jun 20;22(6):363-368. doi: 10.3779/j.issn.1009-3419.2019.06.06.
Tumor spread through air spaces (STAS) as a new pathological invasion mode is closely related to many clinicopathological factors. In lung adenocarcinoma, micropapillary and solid pathological subtypes are most related; STAS for early stage lung adenocarcinoma, surgical type of lobectomy seems to benefit better than sublobar resection, which may up-regulate the pathological stage of early lung cancer; Moreover, STAS is closely related to squamous cell carcinoma and other non-small cell lung cancer (NSCLC). In addition, intraoperative frozen-section pathological detection of STAS is difficult and controversial. STAS as an independent risk factor for tumor recurrence is also an important factor indicating poor prognosis. This paper reviews the research status and progress of STAS. .
肿瘤气腔播散(STAS)作为一种新的病理侵袭模式,与许多临床病理因素密切相关。在肺腺癌中,微乳头和实性病理亚型与之关系最为密切;对于早期肺腺癌的STAS,肺叶切除手术方式似乎比肺段以下切除获益更好,这可能上调早期肺癌的病理分期;此外,STAS与肺鳞癌及其他非小细胞肺癌(NSCLC)密切相关。另外,术中对STAS进行冷冻切片病理检测存在困难且存在争议。STAS作为肿瘤复发的独立危险因素,也是提示预后不良的重要因素。本文综述了STAS的研究现状与进展。