己酮可可碱和柠檬酸西替地尔可改善脱水镰状细胞的可变形性。
Oxpentifylline and cetiedil citrate improve deformability of dehydrated sickle cells.
作者信息
Stuart J, Stone P C, Bilto Y Y, Keidan A J
机构信息
Department of Haematology, Medical School, University of Birmingham.
出版信息
J Clin Pathol. 1987 Oct;40(10):1182-6. doi: 10.1136/jcp.40.10.1182.
Erythrocytes from 14 patients with homozygous sickle cell anaemia were treated with the calcium ionophore A23187 to induce loss of cellular potassium and water. The dehydrated cells showed a decrease in filterability (loss of deformability) through pores of 5 micron diameter. Oxpentifylline and cetiedil citrate, which preserve erythrocyte cation and water content, had a significant (p less than 0.01) protective effect against loss of deformability at a concentration of 1 mumol/l. Oxpentifylline showed no adverse effect on the rheology, morphology, or haemolysis of sickle cells at concentrations up to 500 mumol/l. Drugs that act on the erythrocyte membrane to maintain cell hydration are of potential rheological benefit in sickle cell anaemia.
对14例纯合子镰状细胞贫血患者的红细胞用钙离子载体A23187进行处理，以诱导细胞内钾和水的丢失。脱水细胞通过直径为5微米的孔时滤过性降低（变形性丧失）。能维持红细胞阳离子和水含量的己酮可可碱和柠檬酸西替地尔，在浓度为1微摩尔/升时，对变形性丧失具有显著（p<0.01）的保护作用。在浓度高达500微摩尔/升时，己酮可可碱对镰状细胞的流变学、形态学或溶血均无不良影响。作用于红细胞膜以维持细胞水合作用的药物，对镰状细胞贫血具有潜在的流变学益处。
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