Chen P P, Robbins D L, Jirik F R, Kipps T J, Carson D A
Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, California 92037.
J Exp Med. 1987 Dec 1;166(6):1900-5. doi: 10.1084/jem.166.6.1900.
Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF synthesis. This Vk gene probably encodes at least two 6B6.6 CRI+ RF light chains (Les and Pom) from unrelated subjects, and thus may be related to the light chain-associated 6B6.6 CRI.
此前,我们从人胎盘中分离出一个Vk基因(Humkv325),它编码带有PSL2和PSL3 CRI标记的RF轻链。在此我们报告第二个可用于RF合成的人Vk基因(Humkv328)的分离和特性。这个Vk基因可能编码来自不相关个体的至少两种6B6.6 CRI+ RF轻链(Les和Pom),因此可能与轻链相关的6B6.6 CRI有关。