Barbieri Diego, García-Prieto Ana, Torres Esther, Verde Eduardo, Goicoechea Marian, Luño José
Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Clin Kidney J. 2018 Jul 9;12(3):362-364. doi: 10.1093/ckj/sfy055. eCollection 2019 Jun.
Mixed cryoglobulinaemia (MCG) is one of the most severe extrahepatic hepatitis C virus (HCV)-associated complications, and could involve several organs, including the kidney. MCG prognosis relies on HCV response to antiviral treatment and has changed over the last years, especially after the introduction of new direct acting antivirals (DAA). MCG persistence despite sustained virological response (SVR) is uncommon and has a poorly known meaning and prognosis. We report a case of a patient with chronic HCV infection treated with DAA who developed MCG vasculitis despite the SVR.
混合性冷球蛋白血症（MCG）是最严重的丙型肝炎病毒（HCV）相关肝外并发症之一，可累及包括肾脏在内的多个器官。MCG的预后取决于HCV对抗病毒治疗的反应，并且在过去几年中发生了变化，尤其是在新型直接抗病毒药物（DAA）问世之后。尽管实现了持续病毒学应答（SVR），MCG仍持续存在的情况并不常见，其意义和预后也鲜为人知。我们报告了一例慢性HCV感染患者，该患者接受DAA治疗后，尽管实现了SVR，但仍发生了MCG血管炎。
