使用手性双膦配体的铜催化2H-色烯的不对称硼氢化反应
Copper-Catalyzed Asymmetric Hydroboration of 2 H-Chromenes Using a Chiral Diphosphine Ligand.
作者信息
Li Xiufen, Wang Chaoqiong, Song Jianqiao, Yang Zhihong, Zi Guofu, Hou Guohua
机构信息
Key Laboratory of Radiopharmaceuticals, College of Chemistry , Beijing Normal University , Beijing 100875 , China.
出版信息
J Org Chem. 2019 Jul 5;84(13):8638-8645. doi: 10.1021/acs.joc.9b01109. Epub 2019 Jun 25.
A highly regioselective asymmetric hydroboration of 2 H-chromenes catalyzed by the complex of CuCl and diphosphine ligand ( S, R)-DuanPhos has been realized under mild conditions to produce 3-boryl chromans, achieving good yields and excellent enantioselectivities up to 96% ee. This work provides an efficient approach to the synthesis of chiral 3-boryl chromans and derivatives.
在温和条件下，实现了由氯化铜与二膦配体（S，R）-DuanPhos形成的配合物催化的2H-色烯的高度区域选择性不对称硼氢化反应，生成3-硼基色满，产率良好，对映选择性优异，高达96%ee。这项工作为手性3-硼基色满及其衍生物的合成提供了一种有效方法。
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