Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Physiol Genomics. 2019 Aug 1;51(8):311-322. doi: 10.1152/physiolgenomics.00040.2019. Epub 2019 Jun 14.
Obesity is a causal risk factor for the development of age-related disease conditions, which includes Type 2 diabetes mellitus, cardiovascular disease, and dementia. In genome-wide association studies, genetic variation in is strongly associated with obesity and has been described across different ethnic backgrounds and life stages. To date, much work has been devoted on determining the biological mechanisms via which affects body weight regulation and ultimately contributes to age-related cardiometabolic and brain disease. The main hypotheses of the involved biological mechanisms include the involvement of in habitual food intake and energy expenditure. In this narrative review, our overall aim is to provide an overview on how gene variants could increase the risk of developing age-related disease conditions. Specifically, we will discuss the state of the literature based on the different hypotheses how regulates body weight and ultimately contributes to cardiometabolic disease and brain disease.
肥胖是与年龄相关疾病发展的一个因果风险因素，这些疾病包括 2 型糖尿病、心血管疾病和痴呆。在全基因组关联研究中， 中的遗传变异与肥胖密切相关，并且在不同的种族背景和生命阶段都有描述。迄今为止，大量的工作致力于确定 影响体重调节的生物学机制，最终导致与年龄相关的心脏代谢和脑部疾病。所涉及的生物学机制的主要假设包括 参与习惯性食物摄入和能量消耗。在这篇叙述性综述中，我们的总体目标是提供一个概述，说明 基因变异如何增加与年龄相关疾病的发病风险。具体来说，我们将根据 调节体重并最终导致心脏代谢疾病和脑部疾病的不同假设来讨论文献现状。
