Žikić Dejan, Stojadinović Bojana, Nestorović Zorica
Institute of Biophysics, Faculty of Medicine, University of Belgrade, Belgrade, 11000, Serbia.
Eur Biophys J. 2019 Jul;48(5):407-411. doi: 10.1007/s00249-019-01376-1. Epub 2019 Jun 14.
Biophysical understanding of arterial hemodynamics plays an important role in proper medical diagnosis and investigation of cardiovascular disease pathogens. One of the major cardiovascular parameters is pulse wave velocity (PWV), which depends on the mechanical properties of the arterial wall. The PWV contains information on the condition of the cardiovascular system as well as its physiological age. In humans and most animals, blood flow through the blood vessels is affected by several internal and external forces. The most influencing external force on blood flow is gravity. In the upright position of the body, blood moves from heart to head, opposite to gravity, and from the heart to the legs, in direction of the gravitational force. To investigate how gravity affects PWV, we have developed a biophysical model of cardiovascular system that simulates blood flow in the upright position of the body. The paper presents the results of measurement of PWV in an elastic tube filled with fluids of different viscosities in the gravitational field.
对动脉血流动力学的生物物理理解在心血管疾病病原体的正确医学诊断和研究中起着重要作用。主要的心血管参数之一是脉搏波速度（PWV），它取决于动脉壁的力学特性。PWV包含有关心血管系统状况及其生理年龄的信息。在人类和大多数动物中，血管中的血流受多种内部和外部力量的影响。对血流影响最大的外力是重力。在身体直立时，血液从心脏流向头部，与重力方向相反，从心脏流向腿部，与重力方向一致。为了研究重力如何影响PWV，我们开发了一个心血管系统的生物物理模型，该模型模拟身体直立时的血流。本文介绍了在重力场中充满不同粘度流体的弹性管中测量PWV的结果。
