Duke Neurology, Division of MS and Neuroimmunology, 122 Baker House, Durham, NC 27710, United States.
Duke Neurology, Division of MS and Neuroimmunology, 122 Baker House, Durham, NC 27710, United States.
Mult Scler Relat Disord. 2019 Aug;33:153-157. doi: 10.1016/j.msard.2019.06.003. Epub 2019 Jun 6.
Multiple sclerosis (MS) is a chronic autoimmune condition primarily affecting young adults. As there are numerous uncertainties faced by young women of childbearing age who are living with this chronic condition and the gender ratio is increasingly skewed towards women, it has become critical to define a clear approach to questions of disease management prior to and during pregnancy. With the approval of B cell depletion therapy for treatment of relapsing remitting and primary progressive MS, we explore the available data on using this type of therapy in the setting of pregnancy. We also provide recommendations regarding use of B-cell depleting therapies for patients who are considering or attempting conception.
多发性硬化症（MS）是一种慢性自身免疫性疾病，主要影响年轻人。由于患有这种慢性疾病的育龄年轻女性面临诸多不确定性，且性别比例越来越偏向女性，因此明确疾病管理在怀孕前和怀孕期间的方法至关重要。随着 B 细胞耗竭疗法被批准用于治疗复发缓解型和原发性进展型多发性硬化症，我们探讨了在妊娠期间使用这种疗法的现有数据。我们还就考虑或尝试怀孕的患者使用 B 细胞耗竭疗法提供了建议。
