以及在埃塞俄比亚阿达马公共卫生设施中腹泻患者中的情况：患病率、抗菌药物敏感性模式及相关因素。
and among patients with diarrhea at public health facilities in Adama, Ethiopia: Prevalence, antimicrobial susceptibility pattern, and associated factors.
作者信息
Teshome Bedada, Teklemariam Zelalem, Admassu Ayana Desalegn, Marami Dadi, Asaminew Nega
机构信息
Microbiology Unit, Oromia Public Health Research, Capacity Building and Quality Assurance Laboratory, Adama, Ethiopia.
Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
出版信息
SAGE Open Med. 2019 May 10;7:2050312119846041. doi: 10.1177/2050312119846041. eCollection 2019.
BACKGROUND
The frequent occurrence of bacteria-associated diarrhea together with increased antimicrobial resistance poses a significant public health challenge worldwide.
OBJECTIVES
The aim of this study was to assess the prevalence, antimicrobial susceptibility pattern, and associated factors of and among patients with diarrhea at public health facilities in Adama, Ethiopia.
METHODS
A cross-sectional study was conducted among 232 patients with diarrhea at public health facilities in Adama, Ethiopia, from February 2017 to March 2017. Data were collected using a structured questionnaire. Stool samples were examined for and species using the culture and serological methods. Descriptive statistics were used to summarize the findings. Logistic regression models were used to assess the association of independent variables with the outcome. A -value ⩽ 0.05 was considered to be statistically significant.
RESULTS
The prevalence of and -associated acute diarrhea was 18.1%. The most common isolates were (23.8%) and (21.4%). was 80% resistant to both chloramphenicol and tetracycline. was 66.7% resistant to ampicillin, ciprofloxacin, and tetracycline. Those patients aged 11-20 years (adjusted odds ratio: 4.61, 95% confidence interval: 2.48, 7.34), who feed raw vegetables (adjusted odds ratio: 3.67, 95% confidence interval: 1.32, 8.59), and who did not wash hands with soap before a meal (adjusted odds ratio: 2.68, 95% confidence interval: 1.96, 7.48) and after using the toilet (adjusted odds ratio: 3.25, 95% confidence interval: 1.43, 7.36) had higher odds of acute bacterial diarrhea.
CONCLUSION
and were the major causes of acute diarrhea. Most of the isolates showed resistance to ampicillin, ciprofloxacin, and tetracycline. Patients aged 11-20 years, who feed raw vegetables, and who did not wash hands with soap before the meal and after using the toilet had higher odds of acute bacterial diarrhea. Continuous surveillance and the implementation of infection prevention strategies are needed to mitigate acute bacterial diarrhea.
背景
与细菌相关的腹泻频繁发生，同时抗菌药物耐药性增加，这在全球范围内构成了重大的公共卫生挑战。
目的
本研究旨在评估埃塞俄比亚阿达马公共卫生机构腹泻患者中 及 的患病率、抗菌药物敏感性模式及相关因素。
方法
2017年2月至2017年3月，在埃塞俄比亚阿达马的公共卫生机构对232例腹泻患者进行了一项横断面研究。使用结构化问卷收集数据。采用培养和血清学方法对粪便样本进行 及 菌种检测。使用描述性统计来总结研究结果。采用逻辑回归模型评估自变量与结果之间的关联。P值≤0.05被认为具有统计学意义。
结果
及 相关的急性腹泻患病率为18.1%。最常见的分离株是 （23.8%）和 （21.4%）。 对氯霉素和四环素的耐药率均为80%。 对氨苄西林、环丙沙星和四环素的耐药率为66.7%。年龄在11至20岁的患者（调整后的比值比：4.61，95%置信区间：2.48，7.34）、食用生蔬菜的患者（调整后的比值比：3.67，95%置信区间：1.32，8.59）以及饭前（调整后的比值比：2.68，95%置信区间：1.96，7.48）和便后（调整后的比值比：3.25，95%置信区间：1.43，7.36）未用肥皂洗手的患者发生急性细菌性腹泻的几率更高。
结论
和 是急性腹泻的主要原因。大多数分离株对氨苄西林、环丙沙星和四环素耐药。年龄在11至20岁、食用生蔬菜以及饭前和便后未用肥皂洗手的患者发生急性细菌性腹泻的几率更高。需要持续监测并实施感染预防策略以减轻急性细菌性腹泻。
Zotero 插件