在一部分阿尔茨海默病患者中，基底节受累的tau蛋白病会加重：久山研究。

Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study.

作者信息

Hamasaki Hideomi, Honda Hiroyuki, Suzuki Satoshi O, Shijo Masahiro, Ohara Tomoyuki, Hatabe Yozo, Okamoto Tsuyoshi, Ninomiya Toshiharu, Iwaki Toru

机构信息

Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

出版信息

Alzheimers Dement (Amst). 2019 Jun 6;11:415-423. doi: 10.1016/j.dadm.2019.04.008. eCollection 2019 Dec.

INTRODUCTION

We have conducted the pathological cohort study of autopsied cases of Hisayama residents to reveal a recent trend of dementia-related pathology. We noticed a trend of putaminal involvement of Alzheimer's disease (AD) with parkinsonism. Then, we investigated the accurate prevalence of neurological diseases with putaminal AD pathology in the general population.

METHODS

We examined a series of 291 autopsies in the Hisayama study and performed image analysis of immunohistochemistry for microtubule-associated protein tau (MAPT) and amyloid β.

RESULTS

Approximately 65.6% and 36.1% of cases showed putaminal MAPT and amyloid deposits, respectively. Diffuse deposits of them were mainly found in the AD cases. Putaminal MAPT was highly associated with AD-related pathological criteria. Four of 22 cases with severe putaminal MAPT deposition were documented as having developed parkinsonism.

DISCUSSION

Severe MAPT accumulation in the basal ganglia was closely related to the development of AD pathology and could occur most frequently in AD cases without comorbidities.