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社区为基础的自闭症谱系障碍儿童早期干预的效果:荟萃分析。

Effectiveness of community-based early intervention for children with autism spectrum disorder: a meta-analysis.

机构信息

Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California, Davis, Sacramento, CA, USA.

Center for Mental Health, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

出版信息

J Child Psychol Psychiatry. 2019 Nov;60(11):1200-1209. doi: 10.1111/jcpp.13073. Epub 2019 Jun 17.

Abstract

BACKGROUND

Research trials of early intervention (EI) programs for children with autism spectrum disorder (ASD) generally demonstrate medium-to-large gains, on average, compared with "treatment as usual," in different developmental domains. Almost all children with ASD receive their treatment through community-based services, however, and studies suggest that evidence-based interventions rarely make their way into community practice. Understanding the effectiveness of community-based EI and factors associated with these effects is the first step in developing strategies for wide-scale implementation of effective EI.

METHODS

Studies of community-based EI for children with ASD were identified through a systematic search. Changes in cognitive, communication, social, and adaptive functioning from pre-treatment to post-treatment were assessed using standardized mean gain scores. Effect sizes were estimated using random effects models. Moderators of interest included type of community EI program, year of publication, intervention duration, and sample selection. Moderator effects were assessed using analysis of variance of mixed-effects models and meta-regression analyses.

RESULTS

Forty-six groups from 33 studies met inclusion criteria (1,713 participants, mean age 37.4 months, 81.1% male). There were small but statistically significant gains in each of the four domains. Hedges's g ranged from 0.21 for adaptive behavior to 0.32 for communication outcomes, after removing outliers and correcting for publication bias. EI programs associated with universities and hospitals were superior, on average, to other community EI programs for cognitive and adaptive behavior outcomes. Intervention duration was negatively associated with effect sizes for communication and adaptive behavior outcomes.

CONCLUSIONS

These results indicate that there remains a large gap between outcomes observed in community settings and those reported in efficacy trials.

摘要

背景

自闭症谱系障碍(ASD)儿童的早期干预(EI)研究试验通常与“常规治疗”相比,在不同的发育领域平均显示出中等至较大的收益。然而,几乎所有的 ASD 儿童都是通过社区为基础的服务接受治疗的,并且研究表明,基于证据的干预措施很少能进入社区实践。了解基于社区的 EI 的有效性以及与这些效果相关的因素是制定广泛实施有效 EI 策略的第一步。

方法

通过系统搜索确定了针对 ASD 儿童的基于社区的 EI 研究。使用标准化平均增益分数评估认知、沟通、社交和适应功能从治疗前到治疗后的变化。使用随机效应模型估计效果大小。感兴趣的调节变量包括社区 EI 项目的类型、出版年份、干预持续时间和样本选择。使用混合效应模型的方差分析和元回归分析评估调节效应。

结果

33 项研究中的 46 个小组符合纳入标准(1713 名参与者,平均年龄 37.4 个月,81.1%为男性)。四个领域均有较小但具有统计学意义的收益。在去除异常值并校正出版偏倚后,Hedges 的 g 从适应行为的 0.21 到沟通结果的 0.32 不等。与大学和医院相关的 EI 计划在认知和适应行为结果方面平均优于其他社区 EI 计划。干预持续时间与沟通和适应行为结果的效果大小呈负相关。

结论

这些结果表明,在社区环境中观察到的结果与在疗效试验中报告的结果之间仍然存在很大差距。

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