Institut Curie, PSL Research University, Centre National de La Recherche Scientifique (CNRS), Institut National de la Santé Et de la Recherche Médicale (INSERM), Unité Mixte de Recherche 3347 (UMR), Unité 1021, Orsay, France; Université Paris Sud, Université Paris-Saclay Centre National de La Recherche Scientifique, Unité Mixte de Recherche 3347, Unité 1021, Orsay, France.
Institut Curie, PSL Research University, F-75005 @Paris, France; INSERM, U900, F-75005 Paris, France; MINES ParisTech, PSL Research University CBIO-Centre for Computational Biology, F-75006 Paris, France.
J Mol Biol. 2019 Aug 9;431(17):3056-3067. doi: 10.1016/j.jmb.2019.06.008. Epub 2019 Jun 14.
PRL-3 belongs to the PRL phosphatase family. Its physiological role remains unclear, but many studies have identified that PRL-3 is a marker of cancer progression and shown it to be associated with metastasis. Evidence implicating PRL-3 in various elements of the metastatic process, such as the cell cycle, survival, angiogenesis, adhesion, cytoskeleton remodeling, EMT, motility and invasion, has been reported. Furthermore, several molecules acting as direct or indirect substrates have been identified. However, this information was obtained in many different studies, and it remains difficult to see the larger picture. We therefore systematically collected the published information together and used it to develop a comprehensive signaling network map. By analyzing this network map, we were able to retrieve the signaling pathways via which PRL-3 governs the key steps of the metastatic process in cancer. In this review, we summarize current knowledge of the role of PRL-3 in cancer and the molecular mechanisms involved. We also provide the web-based open-source PRL-3 signaling network map, for use in further studies.
PRL-3 属于 PRL 磷酸酶家族。其生理作用尚不清楚，但许多研究已经确定 PRL-3 是癌症进展的标志物，并表明它与转移有关。有证据表明 PRL-3 参与转移过程的各个环节，如细胞周期、存活、血管生成、黏附、细胞骨架重塑、EMT、运动和侵袭。此外，已经确定了几种作为直接或间接底物的分子。然而，这些信息是在许多不同的研究中获得的，因此仍然很难看到全貌。因此，我们系统地收集了已发表的信息，并将其用于开发全面的信号网络图谱。通过分析这个网络图，我们能够检索出 PRL-3 控制癌症转移过程中关键步骤的信号通路。在这篇综述中，我们总结了 PRL-3 在癌症中的作用及其涉及的分子机制。我们还提供了基于网络的开源 PRL-3 信号网络图谱，供进一步研究使用。
