宿主聚（ADP-核糖）聚合酶（PARPs）在急性和慢性细菌感染中的作用。
Host poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections.
机构信息
Institute of Biomedicine, Research Center for Cancer, Infections, and Immunity, University of Turku, Turku, Finland; Turku Doctoral Programme of Molecular Medicine (TuDMM), University of Turku, Turku, Finland.
Institute of Biomedicine, Research Center for Cancer, Infections, and Immunity, University of Turku, Turku, Finland.
出版信息
Microbes Infect. 2019 Dec;21(10):423-431. doi: 10.1016/j.micinf.2019.06.002. Epub 2019 Jun 15.
Protein ADP-ribosylation is a reversible post-translational modification, which alters protein activity, localization, interactome or stability, leading to perturbation of cell signaling. This review summarizes the emerging data indicating that host cell ADP-ribosylating enzymes, poly(ADP-ribose) polymerases (PARPs), influence the course of a bacterial infection, in parallel to ADP-ribosylating bacterial toxins. Host cell PARP targeting could be an efficient therapeutic approach to treat certain bacterial infections, possibly by repurposing the approved or clinical trial PARP inhibitors developed for cancer therapy.
蛋白质 ADP-核糖基化是一种可逆的翻译后修饰，它改变蛋白质的活性、定位、相互作用或稳定性，从而干扰细胞信号转导。这篇综述总结了新出现的数据，表明宿主细胞 ADP-核糖基化酶，多聚（ADP-核糖）聚合酶（PARP），与 ADP-核糖基化细菌毒素平行地影响细菌感染的过程。靶向宿主细胞 PARP 可能是一种有效的治疗方法，用于治疗某些细菌感染，可能通过重新利用为癌症治疗开发的已批准或临床试验中的 PARP 抑制剂。
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