Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy
Biochem Soc Trans. 2019 Feb 28;47(1):357-370. doi: 10.1042/BST20180416. Epub 2019 Feb 1.
ADP-ribosylation is an ancient and reversible post-translational modification (PTM) of proteins, in which the ADP-ribose moiety is transferred from NAD to target proteins by members of poly-ADP-ribosyl polymerase (PARP) family. The 17 members of this family have been involved in a variety of cellular functions, where their regulatory roles are exerted through the modification of specific substrates, whose identification is crucial to fully define the contribution of this PTM. Evidence of the role of the PARPs is now available both in the context of physiological processes and of cell responses to stress or starvation. An emerging role of the PARPs is their control of intracellular transport, as it is the case for tankyrases/PARP5 and PARP12. Here, we discuss the evidence pointing at this novel aspect of PARPs-dependent cell regulation.
ADP-核糖基化是一种古老且可逆的蛋白质翻译后修饰（PTM），其中 NAD 上的 ADP-核糖部分通过聚 ADP-核糖聚合酶（PARP）家族的成员转移到靶蛋白上。这个家族的 17 个成员参与了多种细胞功能，其调节作用是通过修饰特定的底物来发挥的，而这些底物的鉴定对于充分定义这种 PTM 的贡献至关重要。PARPs 的作用证据现在不仅在生理过程的背景下，而且在细胞对压力或饥饿的反应中都有。PARPs 的一个新作用是它们对细胞内运输的控制，就像 tankyrases/PARP5 和 PARP12 一样。在这里，我们讨论了指向 PARPs 依赖的细胞调节这一新方面的证据。
