Environmental Toxicology & Bioremediation Laboratory, Department of Zoology, University of Lucknow, Lucknow, 226007, India.
Department of Zoology, MJP Rohilkhand University, Bareilly, 243006, India.
Environ Toxicol Pharmacol. 2019 Oct;71:103209. doi: 10.1016/j.etap.2019.103209. Epub 2019 Jun 11.
Ameliorative potential of curcumin against Cr-induced eco-toxicological manifestations was assessed in liver of exposed Channa punctatus (Actinopterygii) in six groups for 45 d; Group I as control. Group II with 3 mg/L of curcumin; group III with 7.89 mg/L of Cr. Groups IV, V and VI were simultaneously co-exposed with 7.89 mg/L of Cr and three different curcumin concentrations, 1, 2, and 3 mg/L, respectively. In group III, SOD-CAT, GR significantly (p < 0.05) increased; decreased GSH level; elevated MN and AC frequencies; and a significant (p < 0.05) up-regulation of cat (2.72-fold), p53 (1.73-fold), bax (1.33-fold) and apaf-1 (2.13-fold) together with a significant (p < 0.05) down-regulation of bcl-2 (0.51-fold). Co-exposure significantly (p < 0.05) brought down activities of SOD-CAT, GR, raised GSH, decreased micronuclei and apoptotic frequencies along with recovery of histopathological anomalies in liver. This study establishes the protective role of curcumin against Cr-induced hepatotoxicity in fish.
姜黄素对 Cr 诱导的生态毒理学表现的改善潜力在 6 组暴露于 Channa punctatus（辐鳍鱼纲）的肝脏中进行了评估；第 I 组为对照组。第 II 组用 3mg/L 的姜黄素；第 III 组用 7.89mg/L 的 Cr。第 IV、V 和 VI 组同时暴露于 7.89mg/L 的 Cr 和三种不同浓度的姜黄素，分别为 1、2 和 3mg/L。在第 III 组中，SOD-CAT、GR 显著（p<0.05）增加；GSH 水平降低；MN 和 AC 频率升高；cat（2.72 倍）、p53（1.73 倍）、bax（1.33 倍）和 apaf-1（2.13 倍）显著上调（p<0.05），bcl-2（0.51 倍）显著下调。共暴露显著（p<0.05）降低了 SOD-CAT、GR 的活性，提高了 GSH，降低了微核和凋亡频率，同时恢复了肝脏的组织病理学异常。本研究确立了姜黄素对鱼类 Cr 诱导肝毒性的保护作用。
