受腐殖酸和氮物种影响的菱形藻中卡马西平的毒性作用和代谢命运。
Toxic effects and metabolic fate of carbamazepine in diatom Navicula sp. as influenced by humic acid and nitrogen species.
机构信息
College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, 518060, China.
Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies, Center for Marine Environmental Chemistry and Toxicology, College of the Environment and Ecology, Xiamen University, Xiamen, 361102, China.
出版信息
J Hazard Mater. 2019 Oct 15;378:120763. doi: 10.1016/j.jhazmat.2019.120763. Epub 2019 Jun 11.
Carbamazepine (CAB) is a commonly detected pharmaceutical in the surface waters. In the present study, we evaluated the effect of humic acid (HA) and nitrogen species on the toxicity of CAB in a typical diatom Navicula sp., and its metabolic fate. The Navicula sp. showed a high sensitivity to CAB (72 h EC = 0.179 mg L). The addition of HA (< 30 mg L) and ammonium could promote the growth of Navicula sp. during 6 d of exposure to CAB. CAB underwent rapid dissipation in the algal culture. The degradation of CAB in Navicula sp. cultures was significantly increased by the addition of HA and higher HA contents caused more degradation of CAB. Degradation and accumulation of CAB in Navicula sp. were significantly inhibited by ammonium. Five metabolites were found and possible degradation pathways of CAB in the algal cell were proposed. Methoxylation, demethylation, glucuronidation and hydroxylation contributed to CAB transformation in the algal cell.
卡马西平（CAB）是地表水中常见的药物。本研究评估了腐殖酸（HA）和氮物种对典型硅藻舟形藻中 CAB 毒性及其代谢命运的影响。舟形藻对 CAB 表现出高敏感性（72 h EC=0.179 mg/L）。在暴露于 CAB 的 6 天内，HA（<30 mg/L）和铵的添加可以促进舟形藻的生长。CAB 在藻类培养中迅速消解。HA 的添加显著增加了 CAB 在舟形藻培养物中的降解，而更高的 HA 含量导致了更多的 CAB 降解。铵显著抑制了 CAB 在舟形藻中的降解和积累。发现了 5 种代谢物，并提出了 CAB 在藻类细胞中的可能降解途径。甲氧基化、脱甲基化、葡萄糖醛酸化和羟化作用有助于 CAB 在藻类细胞中的转化。
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