阿芬太尼在接受手术儿童中的药代动力学

Pharmacokinetics of alfentanil in children undergoing surgery.

作者信息

Roure P, Jean N, Leclerc A C, Cabanel N, Levron J C, Duvaldestin P

机构信息

Département d'Anesthésie, Hôpital Ambroise Paré, Boulogne Billancourt, France.

出版信息

Br J Anaesth. 1987 Nov;59(11):1437-40. doi: 10.1093/bja/59.11.1437.

DOI:10.1093/bja/59.11.1437

PMID:3120765

Abstract

Alfentanil pharmacokinetics and protein binding were determined in 20 children aged 10 months-6.5 yr. The data were compared with those from 10 adult patients. Eighteen children received a single i.v. dose of alfentanil 20 micrograms kg-1. The apparent volume of distribution (V beta) did not differ between the two groups. The degree of plasma protein binding was also similar in children and adults with mean free fractions of 11.5 +/- 0.9% (+/- SD) and 11.8 +/- 3.9%, respectively. There were marked differences in the elimination half-life of alfentanil (63 +/- 24 min in children; 95 +/- 20 min in adults (P less than 0.001] and plasma clearance of alfentanil (11.1 +/- 3.9 ml min-1 kg-1 in children and 5.9 +/- 1.6 ml min-1 kg-1 in adults (P less than 0.001].

摘要

在20名年龄为10个月至6.5岁的儿童中测定了阿芬太尼的药代动力学和蛋白结合情况。将这些数据与10名成年患者的数据进行了比较。18名儿童接受了单次静脉注射20微克/千克的阿芬太尼。两组之间的表观分布容积（Vβ）无差异。儿童和成人的血浆蛋白结合程度也相似，平均游离分数分别为11.5±0.9%（±标准差）和11.8±3.9%。阿芬太尼的消除半衰期（儿童为63±24分钟；成人为95±20分钟（P<0.001））和阿芬太尼的血浆清除率（儿童为11.1±3.9毫升/分钟/千克，成人为5.9±1.6毫升/分钟/千克（P<0.001））存在显著差异。