Laboratoire de virologie, Centre national de référence du virus de l'hépatite E, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, France.
Centre MURAZ, Bobo-Dioulasso, Burkina Faso.
Viruses. 2019 Jun 14;11(6):554. doi: 10.3390/v11060554.
Hepatitis E virus infection is a significant public health problem in many parts of the world including Africa. We tested serum samples from 900 patients in Burkina Faso presenting with febrile icterus. They all tested negative for yellow fever, but those from 23/900 (2.6%) patients contained markers of acute HEV infection (anti-HEV IgM and HEV RNA positive). Genotyping indicated that 14 of the strains were HEV genotype 2b. There was an overall HEV IgG seroprevalence of 18.2% (164/900). In a bivariate analysis, the factors linked to HEV exposure were climate and patient age. Older patients and those living in arid regions were more likely to have HEV infection. HEV genotype 2b circulating only in humans can be involved in some acute febrile icterus cases in Burkina Faso. Better access to safe water, sanitation, and improved personal hygiene should improve control of HEV infection in this country.
戊型肝炎病毒感染是世界上许多地区（包括非洲）的一个重大公共卫生问题。我们检测了来自布基纳法索 900 名发热黄疸患者的血清样本。他们均对黄热病检测呈阴性，但其中 23/900（2.6%）患者的标志物显示急性戊型肝炎病毒感染（抗-HEV IgM 和 HEV RNA 阳性）。基因分型表明，14 株为 HEV 基因型 2b。戊型肝炎病毒 IgG 血清流行率总体为 18.2%（164/900）。在单变量分析中，与戊型肝炎病毒暴露相关的因素是气候和患者年龄。年龄较大的患者和居住在干旱地区的患者更有可能感染戊型肝炎病毒。仅在人类中传播的 2b 基因型戊型肝炎病毒可能与布基纳法索的一些急性发热黄疸病例有关。更好地获得安全用水、改善卫生条件和提高个人卫生水平应有助于控制该国的戊型肝炎病毒感染。
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