A chemical investigation of the fibrous roots of Bge. led to the isolation of four benzophenones, including one new compound () and three known ones (). Comprehensive D, D NMR and HRESIMS data established the structures of the isolated compounds. The absolute configurations were determined by comparison of the calculated optical rotation (OR) with experimental data. All the isolates were evaluated for their cytotoxicities on hepatocellular carcinoma cell lines (HepG2 and Hep3B). Compound showed strong cytotoxicity against HepG2 and Hep3B cells, with IC values at 153.1 and 180.6 nM. Through MTT assay, flow cytometry and Western blot analysis, compound demonstrated the ability to stimulate apoptosis via the NF-κB signaling pathway in HepG2 cells. These benzophenones are potential lead compounds for the development of better treatments for hepatocellular carcinoma.