Bai Changcai, Ye Yunyun, Feng Xiao, Bai Ruifeng, Han Lu, Zhou Xiuping, Yang Xinyao, Tu Pengfei, Chai Xingyun
Key Laboratory of Hui Medicine Modernization, Ministry of Education, Ningxia Medical University Pharmacy College, Yinchuan 750004, China.
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
Molecules. 2017 Apr 17;22(4):642. doi: 10.3390/molecules22040642.
A cytotoxicity-guided phytochemical investigation of roots led to the isolation of six oleanane saponins (-), which were reported from the species for the first time. Their structures were determined by comparing its MS and NMR data with those in literature. Compounds - showed significant inhibitory effects on the proliferation of hepatocellular carcinoma HepG2 cells with IC values ranging from 2.0 to 8.5 μM, compared to positive control methotrexate with IC value of 15.8 μM. Flow cytometry analysis revealed that compounds - exerted anti-proliferative effects through a pro-apoptotic way of hepatocellular carcinoma cells.
对根部进行的细胞毒性导向植物化学研究导致分离出六种齐墩果烷皂苷（-），这是首次从该物种中报道。通过将其质谱和核磁共振数据与文献中的数据进行比较来确定它们的结构。与阳性对照甲氨蝶呤（IC值为15.8 μM）相比，化合物 - 对肝癌HepG2细胞的增殖显示出显著的抑制作用，IC值范围为2.0至8.5 μM。流式细胞术分析表明，化合物 - 通过诱导肝癌细胞凋亡的方式发挥抗增殖作用。
