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血吸虫病中卵周肉芽肿的功能意义

Functional significance of periovular granuloma in schistosomiasis.

作者信息

Reis M G, Andrade Z A

机构信息

Centro de Pesquisas Gonçalo Moniz, Salvador, BA, Brasil.

出版信息

Braz J Med Biol Res. 1987;20(1):55-62.

PMID:3120841
Abstract
  1. Mice infected with 30 Schistosoma mansoni cercariae for 8 weeks presented viable eggs in the tissues up to the 17th day following curative chemotherapy, as demonstrated by the miracidium eclosion test. 2. These results were similar for eggs entrapped within different morphological types of granulomas such as those formed during early or late infection or located in different organs. 3. The present findings indicate that the periovular granuloma occurring in schistosomiasis probably serves to protect the host tissues from the miracidial secretions rather than to attack and kill the miracidium as suggested by previous studies.
摘要
  1. 用30条曼氏血吸虫尾蚴感染小鼠8周后,在进行根治性化疗后的第17天,组织中仍存在活卵,这通过毛蚴孵化试验得到证实。2. 对于被困在不同形态类型肉芽肿内的虫卵,如早期或晚期感染时形成的肉芽肿或位于不同器官中的肉芽肿,结果是相似的。3. 目前的研究结果表明,血吸虫病中出现的虫卵周围肉芽肿可能是为了保护宿主组织免受毛蚴分泌物的侵害,而不是像先前研究所表明的那样攻击并杀死毛蚴。

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