King's College London.
King's College London.
Behav Ther. 2019 Jul;50(4):718-731. doi: 10.1016/j.beth.2018.11.002. Epub 2018 Nov 23.
This study investigated whether a negative interpretation bias was present in people at high risk for psychosis. People with an At Risk Mental State (ARMS; n = 21), patients with First Episode Psychosis (FEP; n = 20), and healthy controls (n = 20) performed three tasks, each of which was designed to measure interpretation bias. Both ARMS and FEP participants showed an attenuated positive bias compared to controls. These findings extend previous results investigating interpretation bias in psychosis by showing that interpretative biases are present before the onset of psychosis, and could therefore contribute to its development. Biased interpretation mechanisms could be a new target for clinical intervention in the early phase of psychosis.
本研究旨在探究处于精神病高危状态的人群是否存在负性解释偏差。研究对象包括有“风险精神状态”（ARMS）的人群（n=21）、首发精神病患者（FEP；n=20）和健康对照组（n=20）。三组人群分别进行了三项任务，旨在测量解释偏差。ARMS 和 FEP 组参与者的正性偏向均弱于对照组。这些发现扩展了之前关于精神病中解释偏差的研究结果，表明解释偏差在精神病发作前就已经存在，因此可能对其发展有影响。有偏差的解释机制可能成为精神病早期临床干预的新靶点。
