癌症中的巨胞饮作用：一个复杂的信号网络
Macropinocytosis in Cancer: A Complex Signaling Network.
作者信息
Zhang Yijuan, Commisso Cosimo
机构信息
Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
出版信息
Trends Cancer. 2019 Jun;5(6):332-334. doi: 10.1016/j.trecan.2019.04.002. Epub 2019 May 9.
Abstract
Macropinocytosis is an important nutrient-scavenging pathway in numerous cancer types, including pancreatic, lung, prostate, and bladder. This Forum highlights recent work identifying the key regulators of macropinocytosis that support tumor cell fitness in different contexts, providing a unique framework for strategies to target macropinocytosis in the treatment of cancer.
摘要
巨吞饮作用是包括胰腺癌、肺癌、前列腺癌和膀胱癌在内的多种癌症类型中一种重要的营养物质清除途径。本论坛重点介绍了近期的研究工作，这些工作确定了在不同情况下支持肿瘤细胞适应性的巨吞饮作用的关键调节因子，为在癌症治疗中靶向巨吞饮作用的策略提供了一个独特的框架。
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