Department of Pathology, Peking University Shenzhen Hospital, Shenzhen, China.
Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, China.
J Clin Pathol. 2019 Aug;72(8):525-528. doi: 10.1136/jclinpath-2019-205913. Epub 2019 Jun 17.
Although ultrastructural studies showed that minute pulmonary meningothelial-like nodules (MPMNs) cells closely resembled meningothelial cells, their immunophenotype has not been well characterised, partly due to their rarity.
Somatostatin receptor 2a (SSTR2a) and other markers of meningioma, including epithelial membrane antigen (EMA), progesterone receptor (PR) and S100, were analysed retrospectively in 19 MPMN cases from two institutions in China.
The median age of patients with MPMNs was 62.5 years (32-73 years), with a male-to-female ratio of 1:8.5. Most (15/19) patients with MPMNs had coexisting diseases, including adenocarcinomas (12 cases), bronchiectasis (1 case) and tuberculosis (2 cases). Just over half of the cases (10/19) were multifocal lesions (2-5 lesions). An additional 53 cases with 123 lesions from the literature were reviewed with reported immunophenotype information. In total, 162 lesions were included in the analysis. The size of nodules was 1-4 mm. All MPMN lesions (39/39) in the 19 cases showed strong and diffuse cytoplasmic expression of SSTR2a. The expression rate of SSTR2a was higher than that of conventional markers of meningioma, including EMA (86/138), PR (32/68) and S100 (1/125).
Our observations expand the spectrum of recognised SSTR2a-positive lesions and once again demonstrated that MPMNs show immunohistochemical characteristics similar to meningothelial cells.
尽管超微结构研究表明微小肺脑膜瘤样结节（MPMNs）细胞与脑膜瘤细胞非常相似，但由于其罕见性，其免疫表型尚未得到很好的描述。
回顾性分析了来自中国两个机构的 19 例 MPMN 病例中生长抑素受体 2a（SSTR2a）和脑膜瘤的其他标志物，包括上皮膜抗原（EMA）、孕激素受体（PR）和 S100。
MPMN 患者的中位年龄为 62.5 岁（32-73 岁），男女比例为 1:8.5。大多数（15/19）MPMN 患者伴有共存疾病，包括腺癌（12 例）、支气管扩张症（1 例）和肺结核（2 例）。超过一半的病例（10/19）为多灶性病变（2-5 个病灶）。另外还回顾了来自文献的 53 例共 123 个病变的病例，报告了免疫表型信息。总共纳入了 162 个结节进行分析。结节大小为 1-4mm。19 例中的所有 MPMN 病变（39/39）均显示 SSTR2a 的强弥漫细胞质表达。SSTR2a 的表达率高于脑膜瘤的常规标志物，包括 EMA（86/138）、PR（32/68）和 S100（1/125）。
我们的观察结果扩展了已知 SSTR2a 阳性病变的范围，并再次证明 MPMNs 具有与脑膜瘤细胞相似的免疫组织化学特征。
