Yang Fei, Sun Yi
Cancer Institute of the Second Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Division of Radiation and Cancer Biology, Departments of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Mol Cell Oncol. 2019 May 8;6(4):1607458. doi: 10.1080/23723556.2019.1607458. eCollection 2019.
F-box protein is a substrate-receptor of SKP1-Cullin1-F-box protein (SCF) E3 ligase, but the function of many family members remains elusive. We found that F-box and WD-repeat domain-containing 2 (FBXW2) inhibits proliferation and invasion of lung cancer cells by targeting S phase kinase-associated protein 2 (SKP2) and β-catenin for degradation. Lower FBXW2 predicts a worse patient survival. Thus, FBXW2 appears a lung tumor suppressor.
F-box蛋白是SKP1-Cullin1-F-box蛋白(SCF)E3连接酶的底物受体,但许多家族成员的功能仍不清楚。我们发现,含F-box和WD重复结构域的蛋白2(FBXW2)通过靶向S期激酶相关蛋白2(SKP2)和β-连环蛋白进行降解,从而抑制肺癌细胞的增殖和侵袭。较低的FBXW2水平预示患者生存期更差。因此,FBXW2似乎是一种肺肿瘤抑制因子。