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本文引用的文献

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Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications.通过组织-分子梯度分析恶性胸膜间皮瘤的异质性，以用于临床应用。
Nat Commun. 2019 Mar 22;10(1):1333. doi: 10.1038/s41467-019-09307-6.
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Nivolumab or nivolumab plus ipilimumab in patients with relapsed malignant pleural mesothelioma (IFCT-1501 MAPS2): a multicentre, open-label, randomised, non-comparative, phase 2 trial.尼伏鲁单抗或尼伏鲁单抗联合伊匹单抗治疗复发恶性胸膜间皮瘤（IFCT-1501 MAPS2）：一项多中心、开放标签、随机、非对照、2 期临床试验。
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Integrative Molecular Characterization of Malignant Pleural Mesothelioma.恶性胸膜间皮瘤的综合分子特征。
Cancer Discov. 2018 Dec;8(12):1548-1565. doi: 10.1158/2159-8290.CD-18-0804. Epub 2018 Oct 15.
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Heterogeneity in Malignant Pleural Mesothelioma.恶性胸膜间皮瘤的异质性。
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Novel therapies for malignant pleural mesothelioma.恶性胸膜间皮瘤的新型治疗方法。
Lancet Oncol. 2018 Mar;19(3):e161-e172. doi: 10.1016/S1470-2045(18)30100-1.
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The Immune Microenvironment, Genome-wide Copy Number Aberrations, and Survival in Mesothelioma.间皮瘤中的免疫微环境、全基因组拷贝数异常与生存
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Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations.恶性胸膜间皮瘤的全面基因组分析鉴定出复发性突变、基因融合和剪接改变。
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通过反卷积方法揭示恶性胸膜间皮瘤的细胞异质性

Unraveling the cellular heterogeneity of malignant pleural mesothelioma through a deconvolution approach.

作者信息

Blum Yuna, Jaurand Marie-Claude, De Reyniès Aurélien, Jean Didier

机构信息

Programme Cartes d'Identité des Tumeurs (CIT), Ligue Nationale Contre Le Cancer, Paris, France.

Centre de Recherche des Cordeliers, Sorbonne Universités, Inserm, Paris, France.

出版信息

Mol Cell Oncol. 2019 May 7;6(4):1610322. doi: 10.1080/23723556.2019.1610322. eCollection 2019.

DOI:10.1080/23723556.2019.1610322
PMID:31211240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6548486/
Abstract

We determined the proportions of epithelioid-like and sarcomatoid-like cellular entities within malignant pleural mesothelioma samples, by deconvolution of their transcriptomes. These proportions are associated with prognosis and may guide therapeutic strategies. This novel approach describes both intra- and inter-tumor heterogeneity and provides a new way of thinking about cancer pathology.

摘要

我们通过对恶性胸膜间皮瘤样本的转录组进行反卷积分析，确定了其中上皮样和肉瘤样细胞实体的比例。这些比例与预后相关，并可能指导治疗策略。这种新方法描述了肿瘤内和肿瘤间的异质性，并为癌症病理学提供了一种新的思考方式。