Fukahori Suguru, Kawahara Hisayoshi, Oyama Takanori, Saito Takeshi, Shimono Ryuichi, Tanaka Aya, Noda Takuo, Hatori Reiko, Fujino Junko, Yagi Minoru
Department of Pediatric Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
Department of Pediatric Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan.
Surg Today. 2020 Jul;50(7):664-671. doi: 10.1007/s00595-019-01833-6. Epub 2019 Jun 18.
Multichannel intraluminal impedance-pH measurements (MII-pH) are useful for evaluating acid and non-acid gastroesophageal reflux (GER). However, the use of MIH-pH is not yet established in Japan. The Japanese Pediatric Impedance Working Group (Japanese-PIG) convened to devise a standard protocol for MII-pH in Japanese children. The expert members of the Japanese-PIG collected data on pediatric MII-pH from the relevant literature in English, including the standard protocol of MII-pH presented by the European PIG, and the insights of international experts. The resultant consensus was included in the contents of the standard protocol of MII-pH. The standard protocol included standardization of the indication, methodology, and interpretation of MII-pH in Japanese children. The criteria for abnormal GER by MII-pH were defined using the Reflux Index and number of total reflux episodes independently in children aged < 1 year and those aged ≥ 1 year. Moreover, a significant relationship between GER and symptoms was identified using the symptom index and symptom association probability approach. We conclude that the current version of the protocol for MII-pH is tentative because it is not based on data from Japanese children. Further studies are needed to render this protocol clinically beneficial and expand its use in Japan.
多通道腔内阻抗 - pH测量（MII - pH）对于评估酸性和非酸性胃食管反流（GER）很有用。然而，MII - pH在日本尚未得到广泛应用。日本儿科阻抗工作组（Japanese - PIG）召开会议，为日本儿童制定MII - pH的标准方案。Japanese - PIG的专家成员从英文相关文献中收集了儿科MII - pH的数据，包括欧洲PIG提出的MII - pH标准方案以及国际专家的见解。由此达成的共识被纳入MII - pH标准方案的内容中。该标准方案包括日本儿童MII - pH适应症、方法和解读的标准化。通过反流指数和总反流发作次数，分别为年龄小于1岁和年龄大于等于1岁的儿童定义了MII - pH诊断GER异常的标准。此外，使用症状指数和症状关联概率方法确定了GER与症状之间的显著关系。我们得出结论，当前版本的MII - pH方案是暂定的，因为它并非基于日本儿童的数据。需要进一步研究以使该方案具有临床实用性并在日本扩大其应用。
