功能磁共振成像研究帕金森病步态障碍：系统评价和探索性 ALE 荟萃分析。
Functional MRI to Study Gait Impairment in Parkinson's Disease: a Systematic Review and Exploratory ALE Meta-Analysis.
机构信息
Department of Rehabilitation Sciences, KU Leuven, Tervuursevest 101, PO Box1501, Leuven, Belgium.
Brain and Mind Centre, University of Sydney, Sydney, Australia.
出版信息
Curr Neurol Neurosci Rep. 2019 Jun 18;19(8):49. doi: 10.1007/s11910-019-0967-2.
PURPOSE OF REVIEW
Whilst gait impairment is a main cause for disability in Parkinson's disease (PD), its neural control remains poorly understood. We performed a systematic review and meta-analysis of neuroimaging studies of surrogate features of gait in PD.
FINDINGS
Assessing the results from PET or SPECT scans after a period of actual walking as well as fMRI during mental imagery or virtual reality (VR) gait paradigms, we found a varying pattern of gait-related brain activity. Overall, a decrease in activation of the SMA during gait was found in PD compared to elderly controls. In addition, the meta-analysis showed that the most consistent gait-related activation was situated in the cerebellar locomotor region (CLR) in PD. Despite methodological heterogeneity, the combined neuroimaging studies of gait provide new insights into its neural control in PD, suggesting that CLR activation likely serves a compensatory role in locomotion.
目的综述
虽然步态障碍是帕金森病（PD）致残的主要原因，但对其神经控制仍知之甚少。我们对 PD 步态替代特征的神经影像学研究进行了系统回顾和荟萃分析。
发现
评估实际行走一段时间后的 PET 或 SPECT 扫描以及想象或虚拟现实（VR）步态范式期间的 fMRI 的结果，我们发现了与步态相关的大脑活动的不同模式。总的来说，与老年对照组相比，PD 患者在行走过程中 SMA 的激活减少。此外，荟萃分析显示，与步态最相关的激活位于 PD 的小脑运动区（CLR）。尽管存在方法学上的异质性，但步态的综合神经影像学研究为其在 PD 中的神经控制提供了新的见解，表明 CLR 的激活可能在运动中起代偿作用。
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