高血压患者中血管紧张素II、肾上腺髓质素及肾上腺髓质素前体循环浓度与左心室肥厚的关系。
Relationship between circulating concentration of Ang II, ADM and ADT and left ventricular hypertrophy in hypertension.
作者信息
Cui Yameng, Zhu Zhenyu, Qi Xin, Li Huihui, Wu Yulin, Chen Wanli, Liu Yue
机构信息
School of Graduate Studies, Tianjin University of Traditional Chinese Medicine Tianjin 300193, China.
Department of Cardiology, Tianjin Union Medical Center Tianjin 300121, China.
出版信息
Am J Transl Res. 2019 May 15;11(5):3167-3175. eCollection 2019.
BACKGROUND
Left ventricular hypertrophy (LVH) is the most common structural damage in hypertensive complication and is an independent risk factor for assessing cardiovascular events. The aim of this study was explore the relationship between plasma concentration of angiotensin II (Ang II), Adrenomedulin (ADM) and adrenotensin (ADT) in patients with hypertension and LVH.
METHODS
We enrolled 310 hypertensive patients from the department of cardiology of Tianjin Union Medical Center as the hypertension group and 39 healthy subjects as control group. Further grouping according to the LVMI (male LVMI≥115 g/m, female LVMI≥95 g/m) values for determining LVH in the 2013 ESC Hypertension Management Guidelines. Plasma levels of Ang II, ADM and ADT were measured using ELISA assay.
RESULTS
The levels of plasma Ang II and ADM in essential hypertension (EH) were significantly higher than control group, and the essential hypertension combined left ventricular hypertrophy (EHCLVH) group was higher than essential hypertension not with left ventricular hypertrophy (EHNLVH) group (<0.05). Correlation analyze showed that left ventricular mass index (LVMI) was positively related to Ang II and ADM, and negatively related to ADT. Logistic regression analyze indicated that LVH are strongly linked with systolic blood pressure (SBP), Ang II, ADM and ADT. ROC curve showed ADM and ADT have similar value in distinguish LVH.
CONCLUSION
Plasma levels of Ang II, ADM and ADT might act as indicator to identify hypertensive LVH.
背景
左心室肥厚（LVH）是高血压并发症中最常见的结构损伤，是评估心血管事件的独立危险因素。本研究旨在探讨高血压合并LVH患者血浆中血管紧张素II（Ang II）、肾上腺髓质素（ADM）和肾上腺紧张素（ADT）浓度之间的关系。
方法
我们选取天津医科大学总医院心内科的310例高血压患者作为高血压组，39例健康受试者作为对照组。根据2013年欧洲心脏病学会（ESC）高血压管理指南中的左心室质量指数（LVMI）（男性LVMI≥115 g/m²，女性LVMI≥95 g/m²）值进一步分组以确定LVH。采用酶联免疫吸附测定（ELISA）法测量血浆中Ang II、ADM和ADT的水平。
结果
原发性高血压（EH）患者血浆Ang II和ADM水平显著高于对照组，原发性高血压合并左心室肥厚（EHCLVH）组高于原发性高血压未合并左心室肥厚（EHNLVH）组（P<0.05）。相关性分析显示，左心室质量指数（LVMI）与Ang II和ADM呈正相关，与ADT呈负相关。Logistic回归分析表明，LVH与收缩压（SBP）、Ang II、ADM和ADT密切相关。ROC曲线显示，ADM和ADT在区分LVH方面具有相似的价值。
结论
血浆Ang II、ADM和ADT水平可能作为识别高血压性LVH的指标。
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